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- W2017258375 abstract "In motor cortex, long-range output to subcortical motor circuits depends on excitatory and inhibitory inputs converging on projection neurons in layers 5A/B. How interneurons interconnect with these projection neurons, and whether these microcircuits are interneuron and/or projection specific, is unclear. We found that fast-spiking interneurons received strong intralaminar (horizontal) excitation from pyramidal neurons in layers 5A/B including corticostriatal and corticospinal neurons, implicating them in mediating disynaptic recurrent, feedforward, and feedback inhibition within and across the two projection classes. Low-threshold-spiking (LTS) interneurons were instead strongly excited by descending interlaminar (vertical) input from layer 2/3 pyramidal neurons, implicating them in mediating disynaptic feedforward inhibition to both projection classes. Furthermore, in a novel pattern, lower layer 2/3 preferentially excited interneurons in one layer (5A/LTS) and excitatory neurons in another (5B/corticospinal). Thus, these inhibitory microcircuits in mouse motor cortex follow an orderly arrangement that is laminarly orthogonalized by interneuron-specific, projection-nonspecific connectivity." @default.
- W2017258375 created "2016-06-24" @default.
- W2017258375 creator A5028877837 @default.
- W2017258375 creator A5044273339 @default.
- W2017258375 creator A5052931874 @default.
- W2017258375 creator A5077161342 @default.
- W2017258375 date "2012-05-16" @default.
- W2017258375 modified "2023-10-13" @default.
- W2017258375 title "Laminarly Orthogonal Excitation of Fast-Spiking and Low-Threshold-Spiking Interneurons in Mouse Motor Cortex" @default.
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- W2017258375 doi "https://doi.org/10.1523/jneurosci.0011-12.2012" @default.
- W2017258375 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3377057" @default.
- W2017258375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22593070" @default.
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