FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017258896> ?p ?o ?g. }

• W2017258896 endingPage "12514" @default.
• W2017258896 startingPage "12504" @default.
• W2017258896 abstract "The ventral bed nucleus of the stria terminalis (vBNST) has been implicated in stress-induced cocaine use. Here we demonstrate that, in the vBNST, corticotropin releasing factor (CRF) is expressed in neurons that innervate the ventral tegmental area (VTA), a site where the CRF receptor antagonist antalarmin prevents the reinstatement of cocaine seeking by a stressor, intermittent footshock, following intravenous self-administration in rats. The vBNST receives dense noradrenergic innervation and expresses β adrenergic receptors (ARs). Footshock-induced reinstatement was prevented by bilateral intra-vBNST injection of the β-2 AR antagonist, ICI-118,551, but not the β-1 AR antagonist, betaxolol. Moreover, bilateral intra-vBNST injection of the β-2 AR agonist, clenbuterol, but not the β-1 agonist, dobutamine, reinstated cocaine seeking, suggesting that activation of vBNST β-2 AR is both necessary for stress-induced reinstatement and sufficient to induce cocaine seeking. The contribution of a β-2 AR-regulated vBNST-to-VTA pathway that releases CRF was investigated using a disconnection approach. Injection of ICI-118,551 into the vBNST in one hemisphere and antalarmin into the VTA of the contralateral hemisphere prevented footshock-induced reinstatement, whereas ipsilateral manipulations failed to attenuate stress-induced cocaine seeking, suggesting that β-2 AR regulate vBNST efferents that release CRF into the VTA, activating CRF receptors, and promoting cocaine use. Last, reinstatement by clenbuterol delivered bilaterally into the vBNST was prevented by bilateral vBNST pretreatment with antalarmin, indicating that β-2 AR-mediated actions in the vBNST also require local CRF receptor activation. Understanding the processes through which stress induces cocaine seeking should guide the development of new treatments for addiction." @default.
• W2017258896 created "2016-06-24" @default.
• W2017258896 creator A5000964272 @default.
• W2017258896 creator A5024580698 @default.
• W2017258896 creator A5024992843 @default.
• W2017258896 creator A5077757829 @default.
• W2017258896 creator A5091237897 @default.
• W2017258896 date "2014-09-10" @default.
• W2017258896 modified "2023-10-17" @default.
• W2017258896 title "Stress-Induced Cocaine Seeking Requires a Beta-2 Adrenergic Receptor-Regulated Pathway from the Ventral Bed Nucleus of the Stria Terminalis That Regulates CRF Actions in the Ventral Tegmental Area" @default.
• W2017258896 cites W1518117902 @default.
• W2017258896 cites W1548131418 @default.
• W2017258896 cites W1597278618 @default.
• W2017258896 cites W1659240124 @default.
• W2017258896 cites W1671645500 @default.
• W2017258896 cites W1754082247 @default.
• W2017258896 cites W1964561961 @default.
• W2017258896 cites W1966073427 @default.
• W2017258896 cites W1968761153 @default.
• W2017258896 cites W1968902260 @default.
• W2017258896 cites W1970920529 @default.
• W2017258896 cites W1979785761 @default.
• W2017258896 cites W1980267862 @default.
• W2017258896 cites W1995790991 @default.
• W2017258896 cites W1997144071 @default.
• W2017258896 cites W1997799210 @default.
• W2017258896 cites W2000280578 @default.
• W2017258896 cites W2003921915 @default.
• W2017258896 cites W2005377956 @default.
• W2017258896 cites W2007111568 @default.
• W2017258896 cites W2008036698 @default.
• W2017258896 cites W2013681235 @default.
• W2017258896 cites W2015034616 @default.
• W2017258896 cites W2015816977 @default.
• W2017258896 cites W2017824803 @default.
• W2017258896 cites W2018571651 @default.
• W2017258896 cites W2020969667 @default.
• W2017258896 cites W2022496443 @default.
• W2017258896 cites W2024482392 @default.
• W2017258896 cites W2024689361 @default.
• W2017258896 cites W2027729485 @default.
• W2017258896 cites W2028219379 @default.
• W2017258896 cites W2030001934 @default.
• W2017258896 cites W2031986822 @default.
• W2017258896 cites W2032692824 @default.
• W2017258896 cites W2033584583 @default.
• W2017258896 cites W2033891792 @default.
• W2017258896 cites W2034530030 @default.
• W2017258896 cites W2042383818 @default.
• W2017258896 cites W2042824787 @default.
• W2017258896 cites W2044823814 @default.
• W2017258896 cites W2051096878 @default.
• W2017258896 cites W2055490134 @default.
• W2017258896 cites W2056877075 @default.
• W2017258896 cites W2065095391 @default.
• W2017258896 cites W2067203693 @default.
• W2017258896 cites W2068015354 @default.
• W2017258896 cites W2068437175 @default.
• W2017258896 cites W2070065061 @default.
• W2017258896 cites W2082146795 @default.
• W2017258896 cites W2094637831 @default.
• W2017258896 cites W2105024315 @default.
• W2017258896 cites W2114622019 @default.
• W2017258896 cites W2118008739 @default.
• W2017258896 cites W2126853419 @default.
• W2017258896 cites W2132807110 @default.
• W2017258896 cites W2135898410 @default.
• W2017258896 cites W2138091294 @default.
• W2017258896 cites W2139476920 @default.
• W2017258896 cites W2140159910 @default.
• W2017258896 cites W2140986639 @default.
• W2017258896 cites W2144851077 @default.
• W2017258896 cites W2146291241 @default.
• W2017258896 cites W2147992522 @default.
• W2017258896 cites W2148895573 @default.
• W2017258896 cites W2154850432 @default.
• W2017258896 cites W2156623031 @default.
• W2017258896 cites W2163815564 @default.
• W2017258896 cites W2166528007 @default.
• W2017258896 cites W2168007598 @default.
• W2017258896 cites W2171968746 @default.
• W2017258896 cites W2443807124 @default.
• W2017258896 doi "https://doi.org/10.1523/jneurosci.0680-14.2014" @default.
• W2017258896 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4160780" @default.
• W2017258896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25209288" @default.
• W2017258896 hasPublicationYear "2014" @default.
• W2017258896 type Work @default.
• W2017258896 sameAs 2017258896 @default.
• W2017258896 citedByCount "67" @default.
• W2017258896 countsByYear W20172588962014 @default.
• W2017258896 countsByYear W20172588962015 @default.
• W2017258896 countsByYear W20172588962016 @default.
• W2017258896 countsByYear W20172588962017 @default.
• W2017258896 countsByYear W20172588962018 @default.
• W2017258896 countsByYear W20172588962019 @default.
• W2017258896 countsByYear W20172588962020 @default.
• W2017258896 countsByYear W20172588962021 @default.
• W2017258896 countsByYear W20172588962022 @default.

• next