FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017260248> ?p ?o ?g. }

• W2017260248 endingPage "227" @default.
• W2017260248 startingPage "222" @default.
• W2017260248 abstract "The aim of the present study was to investigate the role of transient receptor potential vanilloid 4 (TRPV4) in mediating mechanical allodynia in rodent models of chronic compression of the dorsal root ganglion (CCD). First, the levels of TRPV4 mRNA and protein expression in the dorsal root ganglion (DRG) were assessed using real-time RT-PCR and Western blotting analysis respectively at 7, 14, and 28 days post-CCD. Then, the effects of spinal administration of TRPV4 antisense oligodeoxynucleotide (ODN) and mismatch ODN on CCD-induced mechanical allodynia were evaluated. Lastly, the calcium responses to hypotonic solution and 4α-phorbol 12,13-didecanoate (4α-PDD) were assessed following sham surgery, CCD, spinal application of TRPV4 antisense ODN and mismatch ODN. The results showed that the levels of TRPV4 mRNA and protein expression increased significantly at 7–28 days post-CCD when compared with the sham group, with the highest level at 7 days post-CCD. TRPV4 antisense ODN, but not mismatch ODN, partly reversed the CCD-induced mechanical allodynia. Additionally, TRPV4 antisense ODN had no effect on the baseline nociceptive response. The percentage of DRG neurons responsive to hypotonic solution and 4α-PDD and the fluorescence ratio of calcium response were also enhanced significantly in both the CCD group and the mismatch ODN group. These increased responses were significantly inhibited by TRPV4 antisense ODN. In conclusion, TRPV4 plays a crucial role in CCD-induced mechanical allodynia." @default.
• W2017260248 created "2016-06-24" @default.
• W2017260248 creator A5018808903 @default.
• W2017260248 creator A5022802322 @default.
• W2017260248 creator A5045464834 @default.
• W2017260248 creator A5063578056 @default.
• W2017260248 creator A5067510720 @default.
• W2017260248 creator A5078339011 @default.
• W2017260248 date "2008-02-01" @default.
• W2017260248 modified "2023-10-15" @default.
• W2017260248 title "A transient receptor potential vanilloid 4 contributes to mechanical allodynia following chronic compression of dorsal root ganglion in rats" @default.
• W2017260248 cites W1818085992 @default.
• W2017260248 cites W1873187871 @default.
• W2017260248 cites W1965362018 @default.
• W2017260248 cites W1976307713 @default.
• W2017260248 cites W1985501637 @default.
• W2017260248 cites W1998106094 @default.
• W2017260248 cites W1998214061 @default.
• W2017260248 cites W2009367742 @default.
• W2017260248 cites W2011557706 @default.
• W2017260248 cites W2014550477 @default.
• W2017260248 cites W2019592286 @default.
• W2017260248 cites W2022278823 @default.
• W2017260248 cites W2033425777 @default.
• W2017260248 cites W2040318996 @default.
• W2017260248 cites W2040501484 @default.
• W2017260248 cites W2052401001 @default.
• W2017260248 cites W2053530628 @default.
• W2017260248 cites W2061017773 @default.
• W2017260248 cites W2061895140 @default.
• W2017260248 cites W2072942836 @default.
• W2017260248 cites W2097135161 @default.
• W2017260248 cites W2107277218 @default.
• W2017260248 cites W2128498540 @default.
• W2017260248 cites W2128842689 @default.
• W2017260248 cites W2144299211 @default.
• W2017260248 cites W2145692204 @default.
• W2017260248 cites W2146812863 @default.
• W2017260248 cites W2154540873 @default.
• W2017260248 doi "https://doi.org/10.1016/j.neulet.2007.12.028" @default.
• W2017260248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18206306" @default.
• W2017260248 hasPublicationYear "2008" @default.
• W2017260248 type Work @default.
• W2017260248 sameAs 2017260248 @default.
• W2017260248 citedByCount "47" @default.
• W2017260248 countsByYear W20172602482012 @default.
• W2017260248 countsByYear W20172602482013 @default.
• W2017260248 countsByYear W20172602482014 @default.
• W2017260248 countsByYear W20172602482015 @default.
• W2017260248 countsByYear W20172602482016 @default.
• W2017260248 countsByYear W20172602482017 @default.
• W2017260248 countsByYear W20172602482018 @default.
• W2017260248 countsByYear W20172602482019 @default.
• W2017260248 countsByYear W20172602482020 @default.
• W2017260248 countsByYear W20172602482021 @default.
• W2017260248 countsByYear W20172602482022 @default.
• W2017260248 countsByYear W20172602482023 @default.
• W2017260248 crossrefType "journal-article" @default.
• W2017260248 hasAuthorship W2017260248A5018808903 @default.
• W2017260248 hasAuthorship W2017260248A5022802322 @default.
• W2017260248 hasAuthorship W2017260248A5045464834 @default.
• W2017260248 hasAuthorship W2017260248A5063578056 @default.
• W2017260248 hasAuthorship W2017260248A5067510720 @default.
• W2017260248 hasAuthorship W2017260248A5078339011 @default.
• W2017260248 hasConcept C105702510 @default.
• W2017260248 hasConcept C126322002 @default.
• W2017260248 hasConcept C134018914 @default.
• W2017260248 hasConcept C140530291 @default.
• W2017260248 hasConcept C15490471 @default.
• W2017260248 hasConcept C155164980 @default.
• W2017260248 hasConcept C160145004 @default.
• W2017260248 hasConcept C170493617 @default.
• W2017260248 hasConcept C185592680 @default.
• W2017260248 hasConcept C2776281502 @default.
• W2017260248 hasConcept C2777883359 @default.
• W2017260248 hasConcept C2779245659 @default.
• W2017260248 hasConcept C42219234 @default.
• W2017260248 hasConcept C71924100 @default.
• W2017260248 hasConcept C90420996 @default.
• W2017260248 hasConcept C98274493 @default.
• W2017260248 hasConceptScore W2017260248C105702510 @default.
• W2017260248 hasConceptScore W2017260248C126322002 @default.
• W2017260248 hasConceptScore W2017260248C134018914 @default.
• W2017260248 hasConceptScore W2017260248C140530291 @default.
• W2017260248 hasConceptScore W2017260248C15490471 @default.
• W2017260248 hasConceptScore W2017260248C155164980 @default.
• W2017260248 hasConceptScore W2017260248C160145004 @default.
• W2017260248 hasConceptScore W2017260248C170493617 @default.
• W2017260248 hasConceptScore W2017260248C185592680 @default.
• W2017260248 hasConceptScore W2017260248C2776281502 @default.
• W2017260248 hasConceptScore W2017260248C2777883359 @default.
• W2017260248 hasConceptScore W2017260248C2779245659 @default.
• W2017260248 hasConceptScore W2017260248C42219234 @default.
• W2017260248 hasConceptScore W2017260248C71924100 @default.
• W2017260248 hasConceptScore W2017260248C90420996 @default.
• W2017260248 hasConceptScore W2017260248C98274493 @default.
• W2017260248 hasIssue "3" @default.
• W2017260248 hasLocation W20172602481 @default.

• next