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• W2017261703 abstract "MLL gene rearrangements leading to production of MLL fusion proteins are commonly detected in infant leukemia patients; the most common MLL fusion associated with infant leukemia is the MLL-AF4 fusion. A single case of chromosomal rearrangement leading to production of an MLL fusion with AF5Q31, a gene structurally similar to AF4, has been detected recently in the malignant cells of an infant leukemia patient. We have identified a second case of MLL-AF5Q31 fusion, arising from an insertion of MLL sequences into chromosome 5, also in an infant leukemia patient. Because MLL and AF5Q31 are transcribed in opposite orientations, a simple balanced chromosomal translocation cannot produce a fusion protein, and complex chromosomal rearrangements such as insertions and inversions are required to produce an MLL-AF5Q31 fusion protein. This report demonstrates that chromosomal insertion of MLL sequences is a rare but recurrent abnormality associated with infant leukemia." @default.
• W2017261703 created "2016-06-24" @default.
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• W2017261703 creator A5079286374 @default.
• W2017261703 date "2003-04-17" @default.
• W2017261703 modified "2023-10-12" @default.
• W2017261703 title "Insertion ofMLL sequences into chromosome band 5q31 results in anMLL-AF5Q31 fusion and is a rare but recurrent abnormality associated with infant leukemia" @default.
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• W2017261703 doi "https://doi.org/10.1002/gcc.10224" @default.
• W2017261703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12759932" @default.
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