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• W2017262960 abstract "The aim of the present study was to explore the neuroprotective effects of Gynostemma pentaphyllum polysaccharides (GP) in a 1-methyl-4-phenylpyridiniumion (MPP+)-induced cellular model of Parkinson's disease (PD) and the underlying mechanisms. Our results indicated that exposure of PC12 cells to 1 mM MPP+ significantly decreased the cell viability when examined by MTT assay, LDH assay, and annexin-V-FITC and propidium iodide (PI) apoptosis detection assays. MPP+-induced apoptosis in PC12 cells was accompanied by an increased Bax/Bcl-2 ratio, release of mitochondrial cytochrome c into the cytosol, activation of caspase-3/9 and cleavage of poly (ADP-ribose) polymerase (PARP). However, pretreatment of PC12 cells with 50 μg/ml GP prior to MPP+ exposure effectively attenuated the cytotoxicity and improved cell viability via inhibiting elevated Bax/Bcl-2 ratio, as well as the release of cytosolic cytochrome c. Furthermore, GP was effective in attenuating caspase-3/9 activation and cleavage of PARP in MPP+-exposed PC12 cells. These results suggest that the GP has protective effects against MPP+-induced neuronal apoptosis in PC12 cells by suppressing apoptosis-related protein, and therefore, might likely be a promising candidate for the treatment of Parkinson's disease (PD)." @default.
• W2017262960 created "2016-06-24" @default.
• W2017262960 creator A5025649636 @default.
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• W2017262960 date "2014-08-01" @default.
• W2017262960 modified "2023-10-17" @default.
• W2017262960 title "Protective effects of Gynostemma pentaphyllum polysaccharides on PC12 cells impaired by MPP+" @default.
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• W2017262960 doi "https://doi.org/10.1016/j.ijbiomac.2014.05.049" @default.
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