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- W2017263362 abstract "The fluid transport properties of highly permeable dialyzers remain inadequately characterized. We describe a method t measure the local ultrafiltration rate along the length of a highflux dialyzer (SYNTRA.160; Baxter) using a MRI-based technique called 2-D Fourier Transform (2DFT) velocity imaging. Cupric sulfate-doped distilled water was introduced into the dialyzer's blood inlet port at 600 mL/min, with the blood outlet stream recycled to the dialysate inlet port. Local flow velocity was measured at five transverse cross-sectional imaging planes along the dialyzer's length. Based on the assumption of uniform blood compartment flow distribution measured local velocities can be assumed as the velocities in each hollow fiber within a particular imaging planes. After calculation of local blood flow rates from the velocity values and fiber characteristics, local ultrafiltration rates were determined by taking successive differences between the local blood-side flow rates. Our MRI data indicate an exponential decrease in local velocity as a function of axial distance accompanied by a linear decrease in local ultrafiltration rate. In conclusion, the 2DFT velocity imaging technique provides a basis for developing advanced numerical models to predict fluid transport in high-flux dialyzers. This includes the ability to quantify local backfiltration rates under various operating conditions." @default.
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- W2017263362 date "2001-03-01" @default.
- W2017263362 modified "2023-09-24" @default.
- W2017263362 title "MEASUREMENT OF LOCAL ULTRAFILTRATION RATE IN A HEMODIALYZER" @default.
- W2017263362 doi "https://doi.org/10.1097/00002480-200103000-00237" @default.
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