Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017263742> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2017263742 endingPage "523" @default.
- W2017263742 startingPage "518" @default.
- W2017263742 abstract "The local lymph node assay (LLNA) is a skin sensitization test that provides animal welfare benefits. To reduce animal usage further, a modified version (rLLNA) was proposed. Conducting the rLLNA as a screening test with a single high dose group and vehicle control differentiated accurately between skin sensitizers and non-sensitizers. This study examined whether a reduction in animal number/group is feasible. Historical data were utilized to examine the impact of conducting the rLLNA with two mice/group. To assess the effect on the stimulation index (SI) 41 datasets with individual animal data derived using five mice/group were analysed. SIs were calculated on all possible combinations of two control and two high dose group disintegrations per minute (dpm) values. For 25 of 33 sensitizer datasets, > 96% of possible dpm combinations resulted in a calculated SI > 3. The lowest percentages of positive SIs were observed with weak allergens when, in the standard LLNA, the mean SIs would have been nearer to the threshold value of 3. The results indicate that moderate, strong and extreme allergens are more likely than weak allergens to be identified as sensitizers when group sizes of two mice are used within the rLLNA. It is concluded that a rLLNA with two mice/group would display decreased sensitivity and is inappropriate for use in hazard identification. Copyright © 2007 John Wiley & Sons, Ltd." @default.
- W2017263742 created "2016-06-24" @default.
- W2017263742 creator A5005592954 @default.
- W2017263742 creator A5010549809 @default.
- W2017263742 creator A5012592629 @default.
- W2017263742 creator A5019104680 @default.
- W2017263742 creator A5031592925 @default.
- W2017263742 creator A5032355074 @default.
- W2017263742 creator A5034652034 @default.
- W2017263742 creator A5037698678 @default.
- W2017263742 creator A5039090860 @default.
- W2017263742 date "2008-01-01" @default.
- W2017263742 modified "2023-10-11" @default.
- W2017263742 title "The reduced local lymph node assay: the impact of group size" @default.
- W2017263742 cites W1977398085 @default.
- W2017263742 cites W2061715953 @default.
- W2017263742 cites W2088538754 @default.
- W2017263742 cites W2091460982 @default.
- W2017263742 cites W77135042 @default.
- W2017263742 doi "https://doi.org/10.1002/jat.1303" @default.
- W2017263742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17879259" @default.
- W2017263742 hasPublicationYear "2008" @default.
- W2017263742 type Work @default.
- W2017263742 sameAs 2017263742 @default.
- W2017263742 citedByCount "18" @default.
- W2017263742 countsByYear W20172637422012 @default.
- W2017263742 countsByYear W20172637422013 @default.
- W2017263742 countsByYear W20172637422015 @default.
- W2017263742 countsByYear W20172637422016 @default.
- W2017263742 countsByYear W20172637422018 @default.
- W2017263742 countsByYear W20172637422021 @default.
- W2017263742 crossrefType "journal-article" @default.
- W2017263742 hasAuthorship W2017263742A5005592954 @default.
- W2017263742 hasAuthorship W2017263742A5010549809 @default.
- W2017263742 hasAuthorship W2017263742A5012592629 @default.
- W2017263742 hasAuthorship W2017263742A5019104680 @default.
- W2017263742 hasAuthorship W2017263742A5031592925 @default.
- W2017263742 hasAuthorship W2017263742A5032355074 @default.
- W2017263742 hasAuthorship W2017263742A5034652034 @default.
- W2017263742 hasAuthorship W2017263742A5037698678 @default.
- W2017263742 hasAuthorship W2017263742A5039090860 @default.
- W2017263742 hasConcept C203014093 @default.
- W2017263742 hasConcept C2776217527 @default.
- W2017263742 hasConcept C2780614586 @default.
- W2017263742 hasConcept C2780849966 @default.
- W2017263742 hasConcept C3018346242 @default.
- W2017263742 hasConcept C33070731 @default.
- W2017263742 hasConcept C71924100 @default.
- W2017263742 hasConcept C86803240 @default.
- W2017263742 hasConcept C98274493 @default.
- W2017263742 hasConceptScore W2017263742C203014093 @default.
- W2017263742 hasConceptScore W2017263742C2776217527 @default.
- W2017263742 hasConceptScore W2017263742C2780614586 @default.
- W2017263742 hasConceptScore W2017263742C2780849966 @default.
- W2017263742 hasConceptScore W2017263742C3018346242 @default.
- W2017263742 hasConceptScore W2017263742C33070731 @default.
- W2017263742 hasConceptScore W2017263742C71924100 @default.
- W2017263742 hasConceptScore W2017263742C86803240 @default.
- W2017263742 hasConceptScore W2017263742C98274493 @default.
- W2017263742 hasIssue "4" @default.
- W2017263742 hasLocation W20172637421 @default.
- W2017263742 hasLocation W20172637422 @default.
- W2017263742 hasOpenAccess W2017263742 @default.
- W2017263742 hasPrimaryLocation W20172637421 @default.
- W2017263742 hasRelatedWork W1967355125 @default.
- W2017263742 hasRelatedWork W2034475424 @default.
- W2017263742 hasRelatedWork W2042003251 @default.
- W2017263742 hasRelatedWork W2077969598 @default.
- W2017263742 hasRelatedWork W2315794829 @default.
- W2017263742 hasRelatedWork W2610808267 @default.
- W2017263742 hasRelatedWork W3121452689 @default.
- W2017263742 hasRelatedWork W4255520262 @default.
- W2017263742 hasRelatedWork W4280500035 @default.
- W2017263742 hasRelatedWork W83380756 @default.
- W2017263742 hasVolume "28" @default.
- W2017263742 isParatext "false" @default.
- W2017263742 isRetracted "false" @default.
- W2017263742 magId "2017263742" @default.
- W2017263742 workType "article" @default.