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- W2017263787 abstract "Received/Gelis tarihi : August 7, 2013 Accepted/Kabul tarihi : November 5, 2013 To the Editor, Acute lymphoblastic leukemia (ALL) in adults is associated with high relapse rates. Isolated extramedullary relapse other than in the central nervous system is rare in adult females with ALL. We present a case of isolated breast relapse in a 65-year-old female with ALL, mimicking breast cancer. A 65-year old female presented with a 2-month history of fever and generalized lymphadenopathy in December 2006. Physical examination revealed generalized lymphadenopathy and hepatosplenomegaly. Her hemoglobin was 11.9 g/dL, total leukocyte count 9.2x109/L, and platelet count 106x109/L. Peripheral blood smear showed 5% myeloperoxidase-negative blast cells and the bone marrow revealed near total replacement with lymphoblasts (Figures 1A and 1B), which on flow cytometry were positive for CD19 and CD22 and negative for CD10, CD5, and CD7. The cerebrospinal fluid was uninvolved. She was diagnosed with pre-B ALL and received induction as per the MCP-841 protocol [1]. Remission was achieved at the end of induction chemotherapy. Thereafter, she completed intensification, followed by oral maintenance for 1.5 years. Twenty-four months later, she presented with a lump in the left breast. On clinical examination, she had a large, non-tender mass in her left breast with a 1-cm mobile axillary lymph node on the same side. Systemic examination was normal. We considered a diagnosis of breast cancer in view of the classical presentation, supported by a mammogram finding suggestive of Breast Imaging Reporting and Data System Score V (Figures 1C and 1D). Blood counts, peripheral blood smear, and bone" @default.
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- W2017263787 date "2014-06-05" @default.
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- W2017263787 title "Isolated Breast Relapse Mimicking Breast Cancer in Elderly Patient with Acute Lymphoblastic Leukemia" @default.
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- W2017263787 doi "https://doi.org/10.4274/tjh.2013.0270" @default.
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