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- W2017267715 abstract "Acyl carbazates (1) with appropriate substituents are analogs of acyl amino acids in which the α-methine group has been replaced by a nitrogen atom. The synthesis of three new carbazates Ac-Ala-Bzc-ONp, Ac-Ala-Mec-ONp and Z-Ala-Ala-Pro-Mec-ONp (Bzc= NHN(CH2C6H5)CO, Mec= NHN(CH3)CO) was accomplished. The reaction of chymotrypsin, subtilisin BPN′, and elastase (procine and human leukocyte) with the carbazates resulted either in a spectrophotometric burst of p-nitrophenol or no reaction depending on the specificity of the enzyme. Carbazyl chymotrypsin Aα crystals were isomorphous with the native protein. Acyl carbazates should find utility as inhibitors and active site titrants for serine proteases." @default.
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- W2017267715 date "1975-11-01" @default.
- W2017267715 modified "2023-09-25" @default.
- W2017267715 title "Reaction of acyl carbazates with proteolytic enzymes" @default.
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- W2017267715 doi "https://doi.org/10.1016/0006-291x(75)90860-8" @default.
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