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- W2017268527 abstract "We congratulate Austin Ugwumadu and colleagues1Ugwumadu A Manyonda I Reid F Hay P Effect of early oral clindamycin on late miscarriage and preterm delivery in asymptomatic women with abnormal vaginal flora and bacterial vaginosis: a randomised controlled trial.Lancet. 2003; 361: 983-988Summary Full Text Full Text PDF PubMed Scopus (281) Google Scholar on their reporting of important evidence on the role of clindamycin in reducing adverse outcomes in pregnancy. A short oral course of this antibiotic was effective and well tolerated by women identified by a simple screening test, so could be highly cost effective in reducing fetal loss and improving childhood outcomes. We agree that their study needs to be repeated in different settings. Furthermore, new trials should assess mortality, longer-term development, and other childhood outcomes, in addition to preterm birth. Various Cochrane systematic reviews published in early 2003 of trials of antibiotics for various indications in pregnancy showed no evidence of improvement in neonatal outcomes, except for preterm premature rupture of the membranes, in which antibiotics reduced sepsis, respiratory disease, and major cerebral abnormality.2Kenyon S Boulvain M Neilson J Antibiotics for preterm premature rupture of membranes (Cochrane).Database Syst Rev. 2001; 4: CD001058PubMed Google Scholar There was no information at all about outcome in childhood. The case for prevention of infection-associated miscarriages and preterm births in association with recognised risk factors is particularly strong in indigenous communities. Ugwumadu and colleagues' findings should be tested in Australia, since Aboriginal women have substantially increased rates of genitourinary infections, preterm births, and perinatal morbidity and mortality.3Schultz R Read AW Straton JAY Stanley FJ Morich P Genito-urinary tract infections in pregnancy and low birth weight: case-control study in Australian Aboriginal women.BMJ. 1991; 303: 1369-1373Crossref PubMed Scopus (28) Google Scholar, 4Isaacs D Royle JA the Australasian Study Group for Neonatal InfectionsIntrapartum antibiotics and early onset neonatal sepsis caused by group B Streptococcus and by other organisms in Australia.Pediatr Infect Dis J. 1999; 18: 524-528Crossref PubMed Scopus (137) Google Scholar Clindamycin might also have a role in preventing preterm birth and adverse childhood outcomes after preterm premature rupture of the membranes. Effect of oral clindamycin on late miscarriage and preterm deliveryAuthors' reply Full-Text PDF" @default.
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- W2017268527 title "Effect of oral clindamycin on late miscarriage and preterm delivery" @default.
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