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- W2017283553 abstract "Traditionally, the plant Moringa oleifera Lam. (Moringaceae) is used for the treatment of ascites and rheumatism, while the dried seeds of the plant are used as an ‘anti-allergic’ agent. The aim of the study was to assess the efficacy of ethanolic extract of seeds from Moringa oleifera Lam. in experimental immune inflammation. Circulatory and splenic leukocyte counts, delayed-type hypersensitivity reactions and humoral antibody responses were measured in mice using SRBC as the antigen. In addition, macrophage phagocytosis was measured by the carbon clearance test. The extract dose-dependently (50, 100 and 200 mg/kg) inhibited spleen weight as well as circulatory leukocyte and splenocyte counts. The delayed-type hypersensitivity reaction was significantly inhibited (P < 0.01) by decreasing the mean foot pad thickness at 48 h. The production of the humoral antibody titer was significantly ameliorated at a dose of 100 and 200 mg/kg (P < 0.05 and P < 0.01, respectively). Furthermore, the extract caused a down-regulation of macrophage phagocytosis due to carbon particles. Taken together, the above findings suggest that the seeds of Moringa oleifera have immunosuppressive activity." @default.
- W2017283553 created "2016-06-24" @default.
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- W2017283553 date "2010-07-01" @default.
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- W2017283553 title "Immunosuppressive activity of ethanolic extract of seeds of Moringa oleifera Lam. in experimental immune inflammation" @default.
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- W2017283553 doi "https://doi.org/10.1016/j.jep.2010.04.024" @default.
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