FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017283602> ?p ?o ?g. }

• W2017283602 endingPage "1279" @default.
• W2017283602 startingPage "1267" @default.
• W2017283602 abstract "Abstract Hyperglycemia, a symptom of diabetes mellitus, induces hyperosmotic responses, including apoptosis, in vascular endothelial cells and leukocytes. Hyperosmotic shock elicits a stress response in mammalian cells, often leading to apoptotic cell death. In a previous report, we showed that hyperosmotic shock induced apoptosis in various mammalian cells. Importantly, apoptotic biochemical changes (i.e., caspase‐3 activation and DNA fragmentation) were blocked by antioxidant pretreatment during hyperosmotic shock‐induced cell death. In the present study, we report that resveratrol, a phytoalexin present in grapes with known antioxidant and anti‐inflammatory properties, attenuates high glucose‐induced apoptotic changes, including c‐Jun N‐terminal kinase (JNK) activation and caspase‐3 activation in human leukemia K562 cells. Experiments with the cell permeable dye, 2′,7′‐dichlorofluorescein diacetate (DCF‐DA), an indicator of reactive oxygen species (ROS) generation, revealed that high glucose treatment directly increased intracellular oxidative stress, which was attenuated by resveratrol. In addition, high glucose‐treated K562 cells displayed a lower degree of attachment to collagen, the major component of vessel wall subendothelium. In contrast, cells pretreated with resveratrol followed by high glucose exhibited higher affinity for collagen. The results of this report collectively imply the involvement of oxidative stress in high glucose‐induced apoptosis and alterations in attachment ability. Moreover, resveratrol blocks these events by virtue of its antioxidant property. © 2005 Wiley‐Liss, Inc." @default.
• W2017283602 created "2016-06-24" @default.
• W2017283602 creator A5048560198 @default.
• W2017283602 date "2005-02-18" @default.
• W2017283602 modified "2023-10-14" @default.
• W2017283602 title "Effect of resveratrol on high glucose-induced stress in human leukemia K562 cells" @default.
• W2017283602 cites W1512596821 @default.
• W2017283602 cites W157402533 @default.
• W2017283602 cites W1580762299 @default.
• W2017283602 cites W1734082729 @default.
• W2017283602 cites W1856122700 @default.
• W2017283602 cites W1951658941 @default.
• W2017283602 cites W1964314198 @default.
• W2017283602 cites W1969158591 @default.
• W2017283602 cites W1976385326 @default.
• W2017283602 cites W1976929342 @default.
• W2017283602 cites W1978052764 @default.
• W2017283602 cites W1981883990 @default.
• W2017283602 cites W1989969820 @default.
• W2017283602 cites W1997832379 @default.
• W2017283602 cites W2001399809 @default.
• W2017283602 cites W2002610797 @default.
• W2017283602 cites W2016833774 @default.
• W2017283602 cites W2021550936 @default.
• W2017283602 cites W2028169530 @default.
• W2017283602 cites W2038087154 @default.
• W2017283602 cites W2042888176 @default.
• W2017283602 cites W2049110705 @default.
• W2017283602 cites W2050692854 @default.
• W2017283602 cites W2052853635 @default.
• W2017283602 cites W2057810394 @default.
• W2017283602 cites W2057811513 @default.
• W2017283602 cites W2060787688 @default.
• W2017283602 cites W2070834527 @default.
• W2017283602 cites W2071239471 @default.
• W2017283602 cites W2076725548 @default.
• W2017283602 cites W2078901242 @default.
• W2017283602 cites W2079383900 @default.
• W2017283602 cites W2083440657 @default.
• W2017283602 cites W2084609653 @default.
• W2017283602 cites W2092716869 @default.
• W2017283602 cites W2096931514 @default.
• W2017283602 cites W2098036900 @default.
• W2017283602 cites W2098328780 @default.
• W2017283602 cites W2099494773 @default.
• W2017283602 cites W2099675490 @default.
• W2017283602 cites W2117900168 @default.
• W2017283602 cites W2121828312 @default.
• W2017283602 cites W2125947878 @default.
• W2017283602 cites W2128846862 @default.
• W2017283602 cites W2139666587 @default.
• W2017283602 cites W2143333940 @default.
• W2017283602 cites W2148174924 @default.
• W2017283602 cites W2151089147 @default.
• W2017283602 cites W2153133174 @default.
• W2017283602 cites W2158968180 @default.
• W2017283602 cites W2161998935 @default.
• W2017283602 cites W2166185936 @default.
• W2017283602 cites W2169999439 @default.
• W2017283602 cites W24535451 @default.
• W2017283602 cites W4210864717 @default.
• W2017283602 doi "https://doi.org/10.1002/jcb.20408" @default.
• W2017283602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15723279" @default.
• W2017283602 hasPublicationYear "2005" @default.
• W2017283602 type Work @default.
• W2017283602 sameAs 2017283602 @default.
• W2017283602 citedByCount "40" @default.
• W2017283602 countsByYear W20172836022012 @default.
• W2017283602 countsByYear W20172836022013 @default.
• W2017283602 countsByYear W20172836022014 @default.
• W2017283602 countsByYear W20172836022021 @default.
• W2017283602 countsByYear W20172836022022 @default.
• W2017283602 crossrefType "journal-article" @default.
• W2017283602 hasAuthorship W2017283602A5048560198 @default.
• W2017283602 hasConcept C104317684 @default.
• W2017283602 hasConcept C168529131 @default.
• W2017283602 hasConcept C185592680 @default.
• W2017283602 hasConcept C190283241 @default.
• W2017283602 hasConcept C2776151105 @default.
• W2017283602 hasConcept C2776816829 @default.
• W2017283602 hasConcept C31573885 @default.
• W2017283602 hasConcept C48349386 @default.
• W2017283602 hasConcept C55493867 @default.
• W2017283602 hasConcept C86803240 @default.
• W2017283602 hasConcept C95444343 @default.
• W2017283602 hasConceptScore W2017283602C104317684 @default.
• W2017283602 hasConceptScore W2017283602C168529131 @default.
• W2017283602 hasConceptScore W2017283602C185592680 @default.
• W2017283602 hasConceptScore W2017283602C190283241 @default.
• W2017283602 hasConceptScore W2017283602C2776151105 @default.
• W2017283602 hasConceptScore W2017283602C2776816829 @default.
• W2017283602 hasConceptScore W2017283602C31573885 @default.
• W2017283602 hasConceptScore W2017283602C48349386 @default.
• W2017283602 hasConceptScore W2017283602C55493867 @default.
• W2017283602 hasConceptScore W2017283602C86803240 @default.
• W2017283602 hasConceptScore W2017283602C95444343 @default.
• W2017283602 hasIssue "6" @default.
• W2017283602 hasLocation W20172836021 @default.

• next