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• W2017283757 abstract "SLCO1B1 variants are associated with intermediate outcomes that may increase risk of death/myocardial infarction (MI) in statin-treated patients.In high-risk Caucasians undergoing cardiac catheterization, we tested the association between rs4149056/625T>C and rs2306283/492A>G with low-density lipoprotein cholesterol (LDL-c) over 3 years (n = 1402) and death/MI over 6 years (n = 2994), accounting for statin use or type during follow-up.Carriers of the rs4149056 C allele had 6.2 ± 1.7 mg/dl higher LDL-c per C allele (p < 0.001) but were not at higher risk for death/MI (p = 0.9). We found no associations between rs2306283 and LDL-c or death/MI (p > 0.6).Functional SLCO1B1 variants are not associated with death/MI in patients commonly treated with statins, despite higher LDL-c in carriers of the rs4149056 C allele." @default.
• W2017283757 created "2016-06-24" @default.
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• W2017283757 date "2015-04-01" @default.
• W2017283757 modified "2023-10-10" @default.
• W2017283757 title "<i>SLCO1B1</i> genetic variants, long-term low-density lipoprotein cholesterol levels and clinical events in patients following cardiac catheterization" @default.
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• W2017283757 doi "https://doi.org/10.2217/pgs.15.2" @default.
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