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- W2017285626 abstract "Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) has emerged as a powerful metabolic regulator in diverse tissues including fat, skeletal muscle, and the heart. It is now established that activation of PPARbeta/delta promotes fatty acid oxidation in several tissues, such as skeletal muscle and adipose tissue. In muscle, PPARbeta/delta appears to act as a central regulator of fatty acid catabolism. PPARbeta/delta contents are increased in muscle during physiological situations such as physical exercise or long-term fasting, characterized by increased fatty acid oxidation. Targeted expression of an activated form of PPARbeta/delta in skeletal muscle induces a switch to form increased numbers of type I muscle fibers resembling the fiber type transition by endurance training. Activation of PPARbeta/delta also enhances mitochondrial capacity and fat oxidation in the skeletal muscle that resembles the effect of regular exercise. Therefore, it is hypothesized that muscle-specific PPARbeta/delta agonists could be a key strategy to support the poor cardiorespiratory fitness associated with metabolic disorders." @default.
- W2017285626 created "2016-06-24" @default.
- W2017285626 creator A5083143131 @default.
- W2017285626 date "2007-01-01" @default.
- W2017285626 modified "2023-09-30" @default.
- W2017285626 title "Muscle-Specific PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>β</mml:mi><mml:mtext>/</mml:mtext><mml:mi>δ</mml:mi></mml:mrow></mml:math>Agonism May Provide Synergistic Benefits with Life Style Modifications" @default.
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- W2017285626 doi "https://doi.org/10.1155/2007/30578" @default.
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