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- W2017289138 abstract "Recent improvement in modern analytical technologies has stimulated an explosive growth in the study of glycobiology. In turn, this has lead to a richer understanding of the crucial role of N- and O-linked carbohydrates in dictating the properties of the proteins to which they are attached and, in particular, their centrality in the control of protein synthesis, longevity, and activity. Given their importance, it is unsurprising that both gross and subtle defects in glycosylation often contribute to human disease pathology. In this review, we discuss the accumulating evidence for the significance of glycosylation in mediating the functions of the plasma glycoproteins involved in hemostasis and thrombosis. In particular, the role of naturally occurring coagulation protein glycoforms and inherited defects in carbohydrate attachment in modulating coagulation is considered. Finally, we describe the therapeutic opportunities presented by new insights into the role of attached carbohydrates in shaping coagulation protein function and the promise of carbohydrate modification in the delivery of novel therapeutic biologics with enhanced functional properties for the treatment of hemostatic disorders." @default.
- W2017289138 created "2016-06-24" @default.
- W2017289138 creator A5000884311 @default.
- W2017289138 creator A5007517961 @default.
- W2017289138 creator A5026439450 @default.
- W2017289138 creator A5036884964 @default.
- W2017289138 date "2013-05-09" @default.
- W2017289138 modified "2023-09-29" @default.
- W2017289138 title "Elucidating the role of carbohydrate determinants in regulating hemostasis: insights and opportunities" @default.
- W2017289138 cites W135807880 @default.
- W2017289138 cites W1484356035 @default.
- W2017289138 cites W1488243761 @default.
- W2017289138 cites W1502636908 @default.
- W2017289138 cites W1526267572 @default.
- W2017289138 cites W1535383458 @default.
- W2017289138 cites W1539413326 @default.
- W2017289138 cites W1555990693 @default.
- W2017289138 cites W1557915755 @default.
- W2017289138 cites W1576556101 @default.
- W2017289138 cites W1584663505 @default.
- W2017289138 cites W1585764350 @default.
- W2017289138 cites W1585926352 @default.
- W2017289138 cites W1588711507 @default.
- W2017289138 cites W1601837466 @default.
- W2017289138 cites W1601899251 @default.
- W2017289138 cites W1608901332 @default.
- W2017289138 cites W1627204327 @default.
- W2017289138 cites W1637694297 @default.
- W2017289138 cites W1645621228 @default.
- W2017289138 cites W1870828328 @default.
- W2017289138 cites W1963796260 @default.
- W2017289138 cites W1965751405 @default.
- W2017289138 cites W1966569531 @default.
- W2017289138 cites W1969704929 @default.
- W2017289138 cites W1970700288 @default.
- W2017289138 cites W1975434365 @default.
- W2017289138 cites W1989125896 @default.
- W2017289138 cites W1991736711 @default.
- W2017289138 cites W1993862762 @default.
- W2017289138 cites W1996658025 @default.
- W2017289138 cites W1996983268 @default.
- W2017289138 cites W1998419415 @default.
- W2017289138 cites W1999456217 @default.
- W2017289138 cites W2007768414 @default.
- W2017289138 cites W2008104098 @default.
- W2017289138 cites W2010754623 @default.
- W2017289138 cites W2012856058 @default.
- W2017289138 cites W2015591259 @default.
- W2017289138 cites W2019127589 @default.
- W2017289138 cites W2019577213 @default.
- W2017289138 cites W2020363094 @default.
- W2017289138 cites W2021427342 @default.
- W2017289138 cites W2021452548 @default.
- W2017289138 cites W2024186981 @default.
- W2017289138 cites W2024191848 @default.
- W2017289138 cites W2029708892 @default.
- W2017289138 cites W2031723435 @default.
- W2017289138 cites W2036286114 @default.
- W2017289138 cites W2041300580 @default.
- W2017289138 cites W2041661541 @default.
- W2017289138 cites W2047577750 @default.
- W2017289138 cites W2054454598 @default.
- W2017289138 cites W2054626766 @default.
- W2017289138 cites W2055069441 @default.
- W2017289138 cites W2058283617 @default.
- W2017289138 cites W2058714969 @default.
- W2017289138 cites W2058828936 @default.
- W2017289138 cites W2060879419 @default.
- W2017289138 cites W2061785001 @default.
- W2017289138 cites W2066653365 @default.
- W2017289138 cites W2067033925 @default.
- W2017289138 cites W2076654873 @default.
- W2017289138 cites W2077740419 @default.
- W2017289138 cites W2079050804 @default.
- W2017289138 cites W2085006382 @default.
- W2017289138 cites W2086178247 @default.
- W2017289138 cites W2089739309 @default.
- W2017289138 cites W2095764561 @default.
- W2017289138 cites W2098643925 @default.
- W2017289138 cites W2102898028 @default.
- W2017289138 cites W2104785679 @default.
- W2017289138 cites W2108339383 @default.
- W2017289138 cites W2114604545 @default.
- W2017289138 cites W2121120391 @default.
- W2017289138 cites W2121376936 @default.
- W2017289138 cites W2122670476 @default.
- W2017289138 cites W2129097496 @default.
- W2017289138 cites W2131888928 @default.
- W2017289138 cites W2133535267 @default.
- W2017289138 cites W2137300408 @default.
- W2017289138 cites W2140388107 @default.
- W2017289138 cites W2148624878 @default.
- W2017289138 cites W2149369491 @default.
- W2017289138 cites W2150675831 @default.
- W2017289138 cites W2152708819 @default.
- W2017289138 cites W2164619606 @default.
- W2017289138 cites W2168860714 @default.
- W2017289138 cites W2189620872 @default.