FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017291143> ?p ?o ?g. }

• W2017291143 endingPage "992" @default.
• W2017291143 startingPage "980" @default.
• W2017291143 abstract "Stimulation of dopamine (DA) receptors in the striatum evokes a number of alterations in motor behavior in rats, as well as causing several alterations in cellular physiology, including changes in membrane potential, cell excitability, afferent drive, and electrotonic coupling. One cellular property that is potently modulated by DA stimulation is electrotonic coupling, a process shown to subserve motor pattern generation. To examine whether electrotonic coupling plays a role in mediating a specific set of DA receptor-mediated motor behaviors, we tested the effects of two inhibitors of gap junction conductance, carbenoxolone (CARB) and anandamide (AEA), on apomorphine (APO)-induced motor responses. We then used intra-striatal infusions of CARB to determine the role of electrotonic coupling specifically in the ventral striatum in the expression of APO-induced behaviors. APO (2.5-3.0 mg/kg, i.p.) significantly increased motor activity (a composite score) and the frequencies of oral and sniffing stereotypies. APO also disrupted grooming initiation and completion. APO-induced oral stereotypies were selectively blocked by systemic administration of CARB (7.0, 35.0 mg/kg). Moreover, although CARB alone disrupted the initiation and completion of grooming sequences, it also partially normalized APO-induced disruptions in grooming. AEA (0.5, 1.5 mg/kg) also blocked APO-induced oral stereotypies at the higher dose, but differed from CARB in that it did not restore normal grooming behaviors but, instead, appeared to release locomotion. Bilateral infusion of carbenoxolone (50 pmol) into the ventral striatum also blocked the oral stereotypies induced by systemic APO. We conclude from these and previous experiments that gap junctions play an important role in normal motor behavior, and furthermore that disruption of motor behavior in the form of oral and sniffing stereotypies associated with systemic APO administration may be a consequence of this heightened electrotonic coupling in the striatum. These results may be relevant to diseases and pharmacotherapies associated with disruptions of motor and possibly cognitive sequencing." @default.
• W2017291143 created "2016-06-24" @default.
• W2017291143 creator A5017491269 @default.
• W2017291143 creator A5036878613 @default.
• W2017291143 date "2002-12-01" @default.
• W2017291143 modified "2023-10-17" @default.
• W2017291143 title "A Role for Electrotonic Coupling in the Striatum in the Expression of Dopamine Receptor-mediated Stereotypies," @default.
• W2017291143 cites W136076975 @default.
• W2017291143 cites W1571969265 @default.
• W2017291143 cites W1587528652 @default.
• W2017291143 cites W1604918007 @default.
• W2017291143 cites W168407247 @default.
• W2017291143 cites W1775328067 @default.
• W2017291143 cites W1819218275 @default.
• W2017291143 cites W1830687359 @default.
• W2017291143 cites W1912265148 @default.
• W2017291143 cites W1932072959 @default.
• W2017291143 cites W1954186234 @default.
• W2017291143 cites W1966308411 @default.
• W2017291143 cites W1981936285 @default.
• W2017291143 cites W1982004851 @default.
• W2017291143 cites W1984993637 @default.
• W2017291143 cites W1986003147 @default.
• W2017291143 cites W1997809090 @default.
• W2017291143 cites W1998223855 @default.
• W2017291143 cites W2004671175 @default.
• W2017291143 cites W2006751124 @default.
• W2017291143 cites W2007265649 @default.
• W2017291143 cites W2009579516 @default.
• W2017291143 cites W2022395708 @default.
• W2017291143 cites W2028420970 @default.
• W2017291143 cites W2029468394 @default.
• W2017291143 cites W2030465764 @default.
• W2017291143 cites W2030786840 @default.
• W2017291143 cites W2037610573 @default.
• W2017291143 cites W2037785173 @default.
• W2017291143 cites W2040312196 @default.
• W2017291143 cites W2041441236 @default.
• W2017291143 cites W2042301684 @default.
• W2017291143 cites W2042860441 @default.
• W2017291143 cites W2045676110 @default.
• W2017291143 cites W2046663536 @default.
• W2017291143 cites W2046945092 @default.
• W2017291143 cites W2047427997 @default.
• W2017291143 cites W2047810340 @default.
• W2017291143 cites W2048770548 @default.
• W2017291143 cites W2051414078 @default.
• W2017291143 cites W2055223069 @default.
• W2017291143 cites W2055696035 @default.
• W2017291143 cites W2060251672 @default.
• W2017291143 cites W2065522211 @default.
• W2017291143 cites W2069305565 @default.
• W2017291143 cites W2079379899 @default.
• W2017291143 cites W2080433289 @default.
• W2017291143 cites W2082214510 @default.
• W2017291143 cites W2082490117 @default.
• W2017291143 cites W2108861002 @default.
• W2017291143 cites W2117003484 @default.
• W2017291143 cites W2122153276 @default.
• W2017291143 cites W2129076984 @default.
• W2017291143 cites W2131168315 @default.
• W2017291143 cites W2136348943 @default.
• W2017291143 cites W2137027981 @default.
• W2017291143 cites W2144898517 @default.
• W2017291143 cites W2146126558 @default.
• W2017291143 cites W2152717528 @default.
• W2017291143 cites W2153763527 @default.
• W2017291143 cites W2158486426 @default.
• W2017291143 cites W2160607236 @default.
• W2017291143 cites W2163815564 @default.
• W2017291143 cites W2170147327 @default.
• W2017291143 cites W2171377877 @default.
• W2017291143 cites W2172085869 @default.
• W2017291143 cites W2179946274 @default.
• W2017291143 cites W2269195917 @default.
• W2017291143 cites W2341624030 @default.
• W2017291143 cites W2396207454 @default.
• W2017291143 cites W2416196381 @default.
• W2017291143 cites W2418917221 @default.
• W2017291143 cites W2420919685 @default.
• W2017291143 cites W35577062 @default.
• W2017291143 doi "https://doi.org/10.1016/s0893-133x(02)00383-4" @default.
• W2017291143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12464455" @default.
• W2017291143 hasPublicationYear "2002" @default.
• W2017291143 type Work @default.
• W2017291143 sameAs 2017291143 @default.
• W2017291143 citedByCount "69" @default.
• W2017291143 countsByYear W20172911432012 @default.
• W2017291143 countsByYear W20172911432013 @default.
• W2017291143 countsByYear W20172911432014 @default.
• W2017291143 countsByYear W20172911432015 @default.
• W2017291143 countsByYear W20172911432016 @default.
• W2017291143 countsByYear W20172911432017 @default.
• W2017291143 countsByYear W20172911432018 @default.
• W2017291143 countsByYear W20172911432019 @default.
• W2017291143 countsByYear W20172911432020 @default.
• W2017291143 countsByYear W20172911432021 @default.
• W2017291143 countsByYear W20172911432022 @default.

• next