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• W2017295086 abstract "Background and objective Systemically administered lidocaine has been shown to have anti-inflammatory properties. Inhalation is an attractive way of application because of high pulmonary compound concentrations and potentially fewer systemic side effects. The aim of this study was to clarify whether inhaled or, likewise, intravenous lidocaine can attenuate the inflammatory response in a model of experimental endotoxaemia in the rat. Methods Animals randomly received (nine animals in each group) lidocaine, either aerosolized 4 mg kg−1 (LidAe4.0) and 0.4 mg kg−1 (LidAe0.4) or 4 mg kg−1 intravenously (Lidiv) before intravenous injection of 5 mg kg−1 lipopolysaccharide (LPS). Administration of lidocaine was repeated after 2 h. Additional control animals were observed either without (sham) or with the infusion of LPS. Following 5 h of experimental endotoxaemia, the concentrations of tumour necrosis factor α (TNFα), interleukin-1β (IL-1β) and IL-6 were measured in bronchoalveolar lavage fluid and blood plasma. Release of nitrite in ex-vivo cultured alveolar macrophages was measured by Griess assay. Results Bronchoalveolar lavage fluid levels of IL-1β and TNFα in LidAe4.0 (IL-1β, −47%; TNFα, −41%; P < 0.05) and Lidiv (IL-1β, −55%; TNFα, −54%; P < 0.05) but not in LidAe0.4 were significantly lower than in LPS. Plasma cytokine levels were not attenuated. Nitrite was found to be significantly reduced in LidAe4.0 (−46%), LidAe0.4 (−39%) and Lidiv (−41%) when compared with LPS (P < 0.05, respectively). Conclusion Pretreatment of endotoxaemic rats either with LidAe4.0 or with Lidiv attenuated the levels of proinflammatory mediators in bronchoalveolar lavage fluid. Plasma cytokine levels were not affected. Nebulized lidocaine (0.4 mg kg−1) inhibited the nitrite release but did not affect the cytokine levels." @default.
• W2017295086 created "2016-06-24" @default.
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• W2017295086 date "2010-01-01" @default.
• W2017295086 modified "2023-09-26" @default.
• W2017295086 title "Effect of inhaled and intravenous lidocaine on inflammatory reaction in endotoxaemic rats" @default.
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• W2017295086 doi "https://doi.org/10.1097/eja.0b013e32832b8a70" @default.
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