Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017295836> ?p ?o ?g. }
- W2017295836 endingPage "224" @default.
- W2017295836 startingPage "206" @default.
- W2017295836 abstract "Summary: Parasitic protozoa of the genus Leishmania have provided a useful perspective for immunologists in terms of host defense mechanisms critical for the resolution of infection caused by intracellular pathogens. These organisms, which normally reside in a late endosomal, major histocompatibility complex (MHC) class II + compartment within host macrophages cells, require CD4 + T‐cell responses for the control of disease. The paradigm for the CD4 + T‐helper 1 (Th1)/Th2 dichotomy is largely based on the curing/non‐curing responses, respectively, to Leishmania major infection. However, this genus of parasitic protozoa is evolutionarily diverse, with the cutaneous disease‐causing organisms of the Old World ( L. major ) and New World ( Leishmania mexicana/ Leishmania amazonensis ) having diverged 40–80 million years ago. Further adaptations to survive within the visceral organs (for Leishmania donovani , Leishmania chagasi , and Leishmania infantum ) must have been required. Consequently, significant differences in host–parasite interactions have evolved. Different virulence factors have been identified for distinct Leishmania species, and there are profound differences in the immune mechanisms that mediate susceptibility/resistance to infection and in the pathology associated with disease. These variations not only point to interesting features of the host–pathogen interaction and immunobiology of this genus of parasitic protozoa, but also have important implications for immunotherapy and vaccine development." @default.
- W2017295836 created "2016-06-24" @default.
- W2017295836 creator A5017519824 @default.
- W2017295836 creator A5020985367 @default.
- W2017295836 date "2004-09-10" @default.
- W2017295836 modified "2023-10-16" @default.
- W2017295836 title "Does the Leishmania major paradigm of pathogenesis and protection hold for New World cutaneous leishmaniases or the visceral disease?" @default.
- W2017295836 cites W1481185043 @default.
- W2017295836 cites W1483961794 @default.
- W2017295836 cites W1485265843 @default.
- W2017295836 cites W1491819291 @default.
- W2017295836 cites W1497199718 @default.
- W2017295836 cites W1513672361 @default.
- W2017295836 cites W1519859357 @default.
- W2017295836 cites W1525490080 @default.
- W2017295836 cites W1526545436 @default.
- W2017295836 cites W1537582746 @default.
- W2017295836 cites W1552039120 @default.
- W2017295836 cites W1555734844 @default.
- W2017295836 cites W1558591463 @default.
- W2017295836 cites W1562312254 @default.
- W2017295836 cites W1563254333 @default.
- W2017295836 cites W1583505687 @default.
- W2017295836 cites W1590082526 @default.
- W2017295836 cites W1591964260 @default.
- W2017295836 cites W1605265183 @default.
- W2017295836 cites W1609492724 @default.
- W2017295836 cites W1625161850 @default.
- W2017295836 cites W1640137929 @default.
- W2017295836 cites W1674411910 @default.
- W2017295836 cites W1676323055 @default.
- W2017295836 cites W1764091666 @default.
- W2017295836 cites W1767240058 @default.
- W2017295836 cites W1789447249 @default.
- W2017295836 cites W1818696466 @default.
- W2017295836 cites W1818989087 @default.
- W2017295836 cites W1825588133 @default.
- W2017295836 cites W1840084211 @default.
- W2017295836 cites W1851218522 @default.
- W2017295836 cites W1855219841 @default.
- W2017295836 cites W1855297813 @default.
- W2017295836 cites W1880145461 @default.
- W2017295836 cites W1880246550 @default.
- W2017295836 cites W1892413962 @default.
- W2017295836 cites W1898965321 @default.
- W2017295836 cites W1902436298 @default.
- W2017295836 cites W1910765629 @default.
- W2017295836 cites W1917033891 @default.
- W2017295836 cites W1921204067 @default.
- W2017295836 cites W1935267859 @default.
- W2017295836 cites W1935968257 @default.
- W2017295836 cites W1941024190 @default.
- W2017295836 cites W1943484616 @default.
- W2017295836 cites W1958722027 @default.
- W2017295836 cites W1964536035 @default.
- W2017295836 cites W1967160104 @default.
- W2017295836 cites W1970416597 @default.
- W2017295836 cites W1973487069 @default.
- W2017295836 cites W1974428750 @default.
- W2017295836 cites W1975224351 @default.
- W2017295836 cites W1976188303 @default.
- W2017295836 cites W1978801742 @default.
- W2017295836 cites W1980886769 @default.
- W2017295836 cites W1981690800 @default.
- W2017295836 cites W1982030674 @default.
- W2017295836 cites W1986111653 @default.
- W2017295836 cites W1986196570 @default.
- W2017295836 cites W1986367263 @default.
- W2017295836 cites W1986686460 @default.
- W2017295836 cites W1987909356 @default.
- W2017295836 cites W1990999119 @default.
- W2017295836 cites W1995374871 @default.
- W2017295836 cites W1997376856 @default.
- W2017295836 cites W1998187743 @default.
- W2017295836 cites W1998900417 @default.
- W2017295836 cites W2002230372 @default.
- W2017295836 cites W2002505245 @default.
- W2017295836 cites W2002994480 @default.
- W2017295836 cites W2008667963 @default.
- W2017295836 cites W2010002974 @default.
- W2017295836 cites W2013433197 @default.
- W2017295836 cites W2014458069 @default.
- W2017295836 cites W2015681660 @default.
- W2017295836 cites W2018651506 @default.
- W2017295836 cites W2022593038 @default.
- W2017295836 cites W2023900184 @default.
- W2017295836 cites W2023942616 @default.
- W2017295836 cites W2024949498 @default.
- W2017295836 cites W2026676900 @default.
- W2017295836 cites W2036064234 @default.
- W2017295836 cites W2038341140 @default.
- W2017295836 cites W2039070421 @default.
- W2017295836 cites W2040970583 @default.
- W2017295836 cites W2041332092 @default.
- W2017295836 cites W2046195801 @default.
- W2017295836 cites W2048063935 @default.
- W2017295836 cites W2048673212 @default.
- W2017295836 cites W2049977846 @default.