Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017296191> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2017296191 endingPage "2184" @default.
- W2017296191 startingPage "2175" @default.
- W2017296191 abstract "Transgenic mice that express a glucagon gene-simian virus-40 large T-antigen (GLUTag) fusion gene develop neuroendocrine carcinoma of the large bowel. This glucagon-producing tumor was implanted sc and reproducibly formed tumors in nude mice. The transplanted GLUTag tumor expressed large amounts of proglucagon mRNA transcripts, and the levels of proglucagon mRNA transcripts remained constant during 2-8 weeks of tumor growth. The posttranslational processing of proglucagon in the transplantable tumor resembled that detected in the original transgenic tumor, with the liberation of glicentin, oxyntomodulin, glucagon, glucagon-like peptide (1-37) [GLP-1-(1-37)] and GLP-1-(7-37). Tumor-bearing mice demonstrated progressive elevations in the plasma levels of proglucagon-derived peptides. Elevated plasma levels of glucagon-like immunoreactive peptides and immunoreactive glucagon were associated with a marked reduction in the levels of pancreatic glucagon mRNA transcripts by 4 weeks, and after 8 weeks of tumor growth, the levels of glucagon mRNA transcripts in the pancreas were not detectable by Northern blot analysis. Synthesis of the proglucagon-derived peptides was also significantly suppressed at 4-8 weeks in the pancreas of tumor-bearing animals. Histological examination of the endocrine pancreas in mice carrying the GLUTag tumor for 6-8 weeks demonstrated a marked reduction in the number and size of the islets of Langerhans and a disproportionately greater decrease in the number of cells exhibiting glucagon immunoreactivity. By electron microscopy, the residual A-cells were small, compressed at the periphery of the islets, and had poorly developed cytoplasmic organelles. In contrast, no changes in mouse glucagon gene expression or islet morphology were detected in control animals without tumors or mice carrying a sc v-jun-induced fibrosarcoma. The suppression of pancreatic A-cell function and islet size in mice with elevated plasma levels of the proglucagon-derived peptides raises the possibility that a proglucagon-derived peptide may participate in a negative feedback loop, inhibiting expression of the glucagon gene in the A-cells of the endocrine pancreas." @default.
- W2017296191 created "2016-06-24" @default.
- W2017296191 creator A5009878266 @default.
- W2017296191 creator A5057472647 @default.
- W2017296191 creator A5061837667 @default.
- W2017296191 creator A5090794174 @default.
- W2017296191 date "1992-12-01" @default.
- W2017296191 modified "2023-09-27" @default.
- W2017296191 title "Inhibition of pancreatic glucagon gene expression in mice bearing a subcutaneous glucagon-producing GLUTag transplantable tumor." @default.
- W2017296191 cites W1543470256 @default.
- W2017296191 cites W1964212912 @default.
- W2017296191 cites W1966041647 @default.
- W2017296191 cites W2045888668 @default.
- W2017296191 cites W2062278417 @default.
- W2017296191 cites W2065147317 @default.
- W2017296191 cites W2084318057 @default.
- W2017296191 cites W2154895744 @default.
- W2017296191 cites W2482929663 @default.
- W2017296191 doi "https://doi.org/10.1210/mend.6.12.1491697" @default.
- W2017296191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1491697" @default.
- W2017296191 hasPublicationYear "1992" @default.
- W2017296191 type Work @default.
- W2017296191 sameAs 2017296191 @default.
- W2017296191 citedByCount "22" @default.
- W2017296191 countsByYear W20172961912012 @default.
- W2017296191 countsByYear W20172961912017 @default.
- W2017296191 countsByYear W20172961912018 @default.
- W2017296191 countsByYear W20172961912019 @default.
- W2017296191 countsByYear W20172961912020 @default.
- W2017296191 countsByYear W20172961912021 @default.
- W2017296191 countsByYear W20172961912022 @default.
- W2017296191 crossrefType "journal-article" @default.
- W2017296191 hasAuthorship W2017296191A5009878266 @default.
- W2017296191 hasAuthorship W2017296191A5057472647 @default.
- W2017296191 hasAuthorship W2017296191A5061837667 @default.
- W2017296191 hasAuthorship W2017296191A5090794174 @default.
- W2017296191 hasBestOaLocation W20172961911 @default.
- W2017296191 hasConcept C102230213 @default.
- W2017296191 hasConcept C103395026 @default.
- W2017296191 hasConcept C104317684 @default.
- W2017296191 hasConcept C126322002 @default.
- W2017296191 hasConcept C134018914 @default.
- W2017296191 hasConcept C141035611 @default.
- W2017296191 hasConcept C165220095 @default.
- W2017296191 hasConcept C2776398474 @default.
- W2017296191 hasConcept C2777180221 @default.
- W2017296191 hasConcept C2778563252 @default.
- W2017296191 hasConcept C2778764654 @default.
- W2017296191 hasConcept C2779306644 @default.
- W2017296191 hasConcept C2780768396 @default.
- W2017296191 hasConcept C46699223 @default.
- W2017296191 hasConcept C55493867 @default.
- W2017296191 hasConcept C555293320 @default.
- W2017296191 hasConcept C71315377 @default.
- W2017296191 hasConcept C71924100 @default.
- W2017296191 hasConcept C86803240 @default.
- W2017296191 hasConceptScore W2017296191C102230213 @default.
- W2017296191 hasConceptScore W2017296191C103395026 @default.
- W2017296191 hasConceptScore W2017296191C104317684 @default.
- W2017296191 hasConceptScore W2017296191C126322002 @default.
- W2017296191 hasConceptScore W2017296191C134018914 @default.
- W2017296191 hasConceptScore W2017296191C141035611 @default.
- W2017296191 hasConceptScore W2017296191C165220095 @default.
- W2017296191 hasConceptScore W2017296191C2776398474 @default.
- W2017296191 hasConceptScore W2017296191C2777180221 @default.
- W2017296191 hasConceptScore W2017296191C2778563252 @default.
- W2017296191 hasConceptScore W2017296191C2778764654 @default.
- W2017296191 hasConceptScore W2017296191C2779306644 @default.
- W2017296191 hasConceptScore W2017296191C2780768396 @default.
- W2017296191 hasConceptScore W2017296191C46699223 @default.
- W2017296191 hasConceptScore W2017296191C55493867 @default.
- W2017296191 hasConceptScore W2017296191C555293320 @default.
- W2017296191 hasConceptScore W2017296191C71315377 @default.
- W2017296191 hasConceptScore W2017296191C71924100 @default.
- W2017296191 hasConceptScore W2017296191C86803240 @default.
- W2017296191 hasIssue "12" @default.
- W2017296191 hasLocation W20172961911 @default.
- W2017296191 hasLocation W20172961912 @default.
- W2017296191 hasOpenAccess W2017296191 @default.
- W2017296191 hasPrimaryLocation W20172961911 @default.
- W2017296191 hasRelatedWork W2017797235 @default.
- W2017296191 hasRelatedWork W2026675107 @default.
- W2017296191 hasRelatedWork W2049316221 @default.
- W2017296191 hasRelatedWork W2084878141 @default.
- W2017296191 hasRelatedWork W2108282017 @default.
- W2017296191 hasRelatedWork W2143847100 @default.
- W2017296191 hasRelatedWork W2155744960 @default.
- W2017296191 hasRelatedWork W2328774201 @default.
- W2017296191 hasRelatedWork W2508367408 @default.
- W2017296191 hasRelatedWork W251546179 @default.
- W2017296191 hasVolume "6" @default.
- W2017296191 isParatext "false" @default.
- W2017296191 isRetracted "false" @default.
- W2017296191 magId "2017296191" @default.
- W2017296191 workType "article" @default.