FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017297568> ?p ?o ?g. }

• W2017297568 endingPage "292" @default.
• W2017297568 startingPage "282" @default.
• W2017297568 abstract "Dog thyroid epithelial follicular cells in primary culture are quiescent in an insulin-supplemented serum-free medium. They are induced, after a 16- to 20-h prereplicative phase, to synthesize DNA upon stimulation by forskolin, a general adenylate cyclase activator that mimics all the effects of thyrotropin in these cells. The characteristics of adenylate cyclase activation by forskolin make this drug a convenient tool to enhance cellular cyclic AMP levels for well-defined periods of the cell cycle, allowing determination of which parts of the prereplicative phase are controlled by cyclic AMP. We observe that induction of DNA synthesis by forskolin requires its continuous presence for most of the prereplicative phase until a point that little precedes the initiation of DNA replication. Before this point, interruptions in forskolin presence as short as 2 h delay the onset of DNA synthesis, indicating a rapid regression of the cells to an earlier part of G1 from which they can be rescued by forskolin readdition. Similar delays in the onset of S phase are also induced by reversible protein synthesis inhibitions using pulses of cycloheximide. These data suggest that in dog thyrocytes elevated cyclic AMP levels stimulate the progression into G1 phase until a late commitment point before DNA synthesis. This progression depends on peculiarly labile cyclic AMP-stimulated events which might well be the induction by cyclic AMP of the synthesis of labile proteins." @default.
• W2017297568 created "2016-06-24" @default.
• W2017297568 creator A5017958309 @default.
• W2017297568 creator A5019780789 @default.
• W2017297568 creator A5054560560 @default.
• W2017297568 date "1987-10-01" @default.
• W2017297568 modified "2023-09-26" @default.
• W2017297568 title "Regulation of dog thyroid epithelial cell cycle by forskolin, an adenylate cyclase activator" @default.
• W2017297568 cites W1944717769 @default.
• W2017297568 cites W1965978281 @default.
• W2017297568 cites W1969670759 @default.
• W2017297568 cites W1978440762 @default.
• W2017297568 cites W1982273410 @default.
• W2017297568 cites W1990366861 @default.
• W2017297568 cites W1998084165 @default.
• W2017297568 cites W1999111042 @default.
• W2017297568 cites W2000054385 @default.
• W2017297568 cites W2003950207 @default.
• W2017297568 cites W2023419809 @default.
• W2017297568 cites W2028958288 @default.
• W2017297568 cites W2030302920 @default.
• W2017297568 cites W2034248536 @default.
• W2017297568 cites W2042743000 @default.
• W2017297568 cites W2042843602 @default.
• W2017297568 cites W2049228217 @default.
• W2017297568 cites W2050049952 @default.
• W2017297568 cites W2052267527 @default.
• W2017297568 cites W2053823563 @default.
• W2017297568 cites W2065025588 @default.
• W2017297568 cites W2077475937 @default.
• W2017297568 cites W2093884103 @default.
• W2017297568 cites W2121107539 @default.
• W2017297568 cites W2125059344 @default.
• W2017297568 cites W2143837036 @default.
• W2017297568 cites W2164515753 @default.
• W2017297568 doi "https://doi.org/10.1016/0014-4827(87)90387-9" @default.
• W2017297568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2820768" @default.
• W2017297568 hasPublicationYear "1987" @default.
• W2017297568 type Work @default.
• W2017297568 sameAs 2017297568 @default.
• W2017297568 citedByCount "58" @default.
• W2017297568 countsByYear W20172975682015 @default.
• W2017297568 countsByYear W20172975682016 @default.
• W2017297568 countsByYear W20172975682020 @default.
• W2017297568 countsByYear W20172975682022 @default.
• W2017297568 crossrefType "journal-article" @default.
• W2017297568 hasAuthorship W2017297568A5017958309 @default.
• W2017297568 hasAuthorship W2017297568A5019780789 @default.
• W2017297568 hasAuthorship W2017297568A5054560560 @default.
• W2017297568 hasConcept C104317684 @default.
• W2017297568 hasConcept C126322002 @default.
• W2017297568 hasConcept C134018914 @default.
• W2017297568 hasConcept C1491633281 @default.
• W2017297568 hasConcept C153911025 @default.
• W2017297568 hasConcept C180526460 @default.
• W2017297568 hasConcept C181199279 @default.
• W2017297568 hasConcept C24998067 @default.
• W2017297568 hasConcept C2778128677 @default.
• W2017297568 hasConcept C2779276759 @default.
• W2017297568 hasConcept C2780069284 @default.
• W2017297568 hasConcept C29537977 @default.
• W2017297568 hasConcept C3675279 @default.
• W2017297568 hasConcept C552990157 @default.
• W2017297568 hasConcept C55493867 @default.
• W2017297568 hasConcept C64241487 @default.
• W2017297568 hasConcept C71924100 @default.
• W2017297568 hasConcept C86803240 @default.
• W2017297568 hasConcept C88045685 @default.
• W2017297568 hasConcept C95444343 @default.
• W2017297568 hasConceptScore W2017297568C104317684 @default.
• W2017297568 hasConceptScore W2017297568C126322002 @default.
• W2017297568 hasConceptScore W2017297568C134018914 @default.
• W2017297568 hasConceptScore W2017297568C1491633281 @default.
• W2017297568 hasConceptScore W2017297568C153911025 @default.
• W2017297568 hasConceptScore W2017297568C180526460 @default.
• W2017297568 hasConceptScore W2017297568C181199279 @default.
• W2017297568 hasConceptScore W2017297568C24998067 @default.
• W2017297568 hasConceptScore W2017297568C2778128677 @default.
• W2017297568 hasConceptScore W2017297568C2779276759 @default.
• W2017297568 hasConceptScore W2017297568C2780069284 @default.
• W2017297568 hasConceptScore W2017297568C29537977 @default.
• W2017297568 hasConceptScore W2017297568C3675279 @default.
• W2017297568 hasConceptScore W2017297568C552990157 @default.
• W2017297568 hasConceptScore W2017297568C55493867 @default.
• W2017297568 hasConceptScore W2017297568C64241487 @default.
• W2017297568 hasConceptScore W2017297568C71924100 @default.
• W2017297568 hasConceptScore W2017297568C86803240 @default.
• W2017297568 hasConceptScore W2017297568C88045685 @default.
• W2017297568 hasConceptScore W2017297568C95444343 @default.
• W2017297568 hasIssue "2" @default.
• W2017297568 hasLocation W20172975681 @default.
• W2017297568 hasLocation W20172975682 @default.
• W2017297568 hasOpenAccess W2017297568 @default.
• W2017297568 hasPrimaryLocation W20172975681 @default.
• W2017297568 hasRelatedWork W1595112378 @default.
• W2017297568 hasRelatedWork W2017297568 @default.
• W2017297568 hasRelatedWork W2027266387 @default.
• W2017297568 hasRelatedWork W2029369136 @default.

• next