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• W2017297714 endingPage "471" @default.
• W2017297714 startingPage "463" @default.
• W2017297714 abstract "The human genetic disorder ataxia telangiectasia (A-T), caused by mutation in the ATM gene, is characterized by chromosomal instability, radiosensitivity and defective cell cycle checkpoint activation. DNA double-strand breaks (dsbs) persist in A-T cells after irradiation, but the underlying defect is unclear. To investigate ATM's interactions with dsb repair pathways, we disrupted ATM along with other genes involved in the principal, complementary dsb repair pathways of homologous recombination (HR) or non-homologous end-joining (NHEJ) in chicken DT40 cells. ATM(-/-) cells show altered kinetics of radiation-induced Rad51 and Rad54 focus formation. Ku70-deficient (NHEJ(-)) ATM(-/-) chicken DT40 cells show radiosensitivity and high radiation-induced chromosomal aberration frequencies, while Rad54-defective (HR(-)) ATM(-/-) cells show only slightly elevated aberration levels after irradiation, placing ATM and HR on the same pathway. These results reveal that ATM defects impair HR-mediated dsb repair and may link cell cycle checkpoints to HR activation." @default.
• W2017297714 created "2016-06-24" @default.
• W2017297714 creator A5021997293 @default.
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• W2017297714 date "2000-02-01" @default.
• W2017297714 modified "2023-10-09" @default.
• W2017297714 title "The controlling role of ATM in homologous recombinational repair of DNA damage" @default.
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• W2017297714 cites W1965461792 @default.
• W2017297714 cites W1967660527 @default.
• W2017297714 cites W1972250965 @default.
• W2017297714 cites W1973063910 @default.
• W2017297714 cites W1973085375 @default.
• W2017297714 cites W1973771911 @default.
• W2017297714 cites W1980737084 @default.
• W2017297714 cites W1985544638 @default.
• W2017297714 cites W1986179131 @default.
• W2017297714 cites W1987345634 @default.
• W2017297714 cites W1988876917 @default.
• W2017297714 cites W1994163195 @default.
• W2017297714 cites W2003832230 @default.
• W2017297714 cites W2004486431 @default.
• W2017297714 cites W2005275397 @default.
• W2017297714 cites W2008684482 @default.
• W2017297714 cites W2011881129 @default.
• W2017297714 cites W2016492620 @default.
• W2017297714 cites W2017145640 @default.
• W2017297714 cites W2027223119 @default.
• W2017297714 cites W2028305335 @default.
• W2017297714 cites W2030502631 @default.
• W2017297714 cites W2031863792 @default.
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• W2017297714 cites W2035277099 @default.
• W2017297714 cites W2040960949 @default.
• W2017297714 cites W2046589688 @default.
• W2017297714 cites W2046994769 @default.
• W2017297714 cites W2048458949 @default.
• W2017297714 cites W2051214017 @default.
• W2017297714 cites W2058800908 @default.
• W2017297714 cites W2059956556 @default.
• W2017297714 cites W2074726130 @default.
• W2017297714 cites W2078242581 @default.
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• W2017297714 cites W2089574530 @default.
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• W2017297714 doi "https://doi.org/10.1093/emboj/19.3.463" @default.
• W2017297714 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/305583" @default.
• W2017297714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10654944" @default.
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