Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017298009> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2017298009 endingPage "1364" @default.
- W2017298009 startingPage "1353" @default.
- W2017298009 abstract "Antigen receptors on T and B cells function to transduce signals leading to a variety of biologic responses minimally including antigen receptor editing, apoptotic death, developmental progression, cell activation, proliferation and survival. The response to antigen depends upon antigen affinity and valence, involvement of coreceptors in signaling and differentiative stage of the responding cell. The requirement that these receptors integrate signals that drive an array of responses may explain their evolved structural complexity. Antigen receptors are composed of multiple subunits compartmentalized to provide antigen recognition and signal transduction function. In lieu of on-board enzymatic activity these receptors rely on associated Protein Tyrosine Kinases (PTKs) for their signaling function. By aggregating the receptors, and hence their appended PTKs, antigens induce PTK transphosphorylation, activating them to phosphorylate the receptor within conserved motifs termed Immunoreceptor Tyrosine-based Activation Motifs (ITAMs) found in transducer subunits. The tyrosyl phosphorylated ITAMs then interact with Src Homology 2 (SH2) domains within the PTKs leading to their further activation. As receptor phosphorylation is amplified, other effectors, such as Shc, dock by virtue of SH2 binding, and serve, in-turn, as substrates for these PTKs. This sequence of events not only provides a signal amplification mechanism by combining multiple consecutive steps with positive feedback, but also allows for signal diversification by differential recruitment of effectors that provide access to distinct parallel downstream signaling pathways. The subject of antigen receptor signaling has been recently reviewed in depth (; ). Here we discuss the biochemical basis of antigen receptor signal transduction, using the B cell receptor (BCR) as a paradigm, with specific emphasis on the involved PTKs. We review several specific mechanisms by which responses through these receptors are propagated and modified by accessory molecules, and discuss how signal amplification and diversification are achieved." @default.
- W2017298009 created "2016-06-24" @default.
- W2017298009 creator A5036927381 @default.
- W2017298009 creator A5063233755 @default.
- W2017298009 date "1998-09-17" @default.
- W2017298009 modified "2023-10-17" @default.
- W2017298009 title "Antigen receptor signaling: integration of protein tyrosine kinase functions" @default.
- W2017298009 doi "https://doi.org/10.1038/sj.onc.1202187" @default.
- W2017298009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9779983" @default.
- W2017298009 hasPublicationYear "1998" @default.
- W2017298009 type Work @default.
- W2017298009 sameAs 2017298009 @default.
- W2017298009 citedByCount "104" @default.
- W2017298009 countsByYear W20172980092012 @default.
- W2017298009 countsByYear W20172980092013 @default.
- W2017298009 countsByYear W20172980092014 @default.
- W2017298009 countsByYear W20172980092015 @default.
- W2017298009 countsByYear W20172980092017 @default.
- W2017298009 countsByYear W20172980092018 @default.
- W2017298009 countsByYear W20172980092019 @default.
- W2017298009 countsByYear W20172980092020 @default.
- W2017298009 countsByYear W20172980092021 @default.
- W2017298009 countsByYear W20172980092022 @default.
- W2017298009 crossrefType "journal-article" @default.
- W2017298009 hasAuthorship W2017298009A5036927381 @default.
- W2017298009 hasAuthorship W2017298009A5063233755 @default.
- W2017298009 hasBestOaLocation W20172980091 @default.
- W2017298009 hasConcept C101544691 @default.
- W2017298009 hasConcept C108636557 @default.
- W2017298009 hasConcept C11960822 @default.
- W2017298009 hasConcept C147483822 @default.
- W2017298009 hasConcept C157695867 @default.
- W2017298009 hasConcept C159654299 @default.
- W2017298009 hasConcept C170493617 @default.
- W2017298009 hasConcept C19317047 @default.
- W2017298009 hasConcept C197153747 @default.
- W2017298009 hasConcept C203014093 @default.
- W2017298009 hasConcept C2776090121 @default.
- W2017298009 hasConcept C2777553839 @default.
- W2017298009 hasConcept C2778453870 @default.
- W2017298009 hasConcept C29907709 @default.
- W2017298009 hasConcept C35174551 @default.
- W2017298009 hasConcept C42362537 @default.
- W2017298009 hasConcept C55493867 @default.
- W2017298009 hasConcept C62478195 @default.
- W2017298009 hasConcept C86803240 @default.
- W2017298009 hasConcept C8891405 @default.
- W2017298009 hasConcept C95444343 @default.
- W2017298009 hasConceptScore W2017298009C101544691 @default.
- W2017298009 hasConceptScore W2017298009C108636557 @default.
- W2017298009 hasConceptScore W2017298009C11960822 @default.
- W2017298009 hasConceptScore W2017298009C147483822 @default.
- W2017298009 hasConceptScore W2017298009C157695867 @default.
- W2017298009 hasConceptScore W2017298009C159654299 @default.
- W2017298009 hasConceptScore W2017298009C170493617 @default.
- W2017298009 hasConceptScore W2017298009C19317047 @default.
- W2017298009 hasConceptScore W2017298009C197153747 @default.
- W2017298009 hasConceptScore W2017298009C203014093 @default.
- W2017298009 hasConceptScore W2017298009C2776090121 @default.
- W2017298009 hasConceptScore W2017298009C2777553839 @default.
- W2017298009 hasConceptScore W2017298009C2778453870 @default.
- W2017298009 hasConceptScore W2017298009C29907709 @default.
- W2017298009 hasConceptScore W2017298009C35174551 @default.
- W2017298009 hasConceptScore W2017298009C42362537 @default.
- W2017298009 hasConceptScore W2017298009C55493867 @default.
- W2017298009 hasConceptScore W2017298009C62478195 @default.
- W2017298009 hasConceptScore W2017298009C86803240 @default.
- W2017298009 hasConceptScore W2017298009C8891405 @default.
- W2017298009 hasConceptScore W2017298009C95444343 @default.
- W2017298009 hasIssue "11" @default.
- W2017298009 hasLocation W20172980091 @default.
- W2017298009 hasLocation W20172980092 @default.
- W2017298009 hasOpenAccess W2017298009 @default.
- W2017298009 hasPrimaryLocation W20172980091 @default.
- W2017298009 hasRelatedWork W166557536 @default.
- W2017298009 hasRelatedWork W1886292263 @default.
- W2017298009 hasRelatedWork W1967416080 @default.
- W2017298009 hasRelatedWork W1983960385 @default.
- W2017298009 hasRelatedWork W1992911312 @default.
- W2017298009 hasRelatedWork W2009481807 @default.
- W2017298009 hasRelatedWork W2030277142 @default.
- W2017298009 hasRelatedWork W2067884008 @default.
- W2017298009 hasRelatedWork W2079992380 @default.
- W2017298009 hasRelatedWork W2945181102 @default.
- W2017298009 hasVolume "17" @default.
- W2017298009 isParatext "false" @default.
- W2017298009 isRetracted "false" @default.
- W2017298009 magId "2017298009" @default.
- W2017298009 workType "article" @default.