Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017299012> ?p ?o ?g. }
- W2017299012 endingPage "190" @default.
- W2017299012 startingPage "183" @default.
- W2017299012 abstract "Psoriasis is a genetically determined, almost worldwide-distributed inflammatory skin disease with overall higher prevalence among people of northern European ancestry. Since enhanced innate immunity is an important feature of the pathophysiology of this disease, it has been proposed that differences in the prevalence of psoriasis in different populations mainly result from differences in natural selection for gene polymorphisms associated with more vigorous immunity against infectious agents. However the infectious agent(s) that could have acted upon human population as selection pressure for psoriasis is still obscure. Based on the remarkable clinical observation that psoriasis and leprosy are almost mutually exclusive, a fact that is further supported by divergent HLA patterns in patients with psoriasis and leprosy we propose that resisting leprosy may have been the evolutionary advantage that favoured the expansion of some psoriasis-associated genotypes especially in the progenitors of modern Europeans. Moreover, we suggest that the spreading out of a certain genetic resistance trait may offer a supplementary explanation for the better understanding of the relatively rapid decline of leprosy in the late medieval epoch in Europe. Both genetic and paleoepidemiologic methods could be employed in order to challenge the present hypothesis." @default.
- W2017299012 created "2016-06-24" @default.
- W2017299012 creator A5021354047 @default.
- W2017299012 creator A5037394809 @default.
- W2017299012 creator A5081961495 @default.
- W2017299012 date "2012-01-01" @default.
- W2017299012 modified "2023-10-15" @default.
- W2017299012 title "Leprosy and the natural selection for psoriasis" @default.
- W2017299012 cites W151366572 @default.
- W2017299012 cites W1594407028 @default.
- W2017299012 cites W1914199395 @default.
- W2017299012 cites W1963671590 @default.
- W2017299012 cites W1964382953 @default.
- W2017299012 cites W1964497532 @default.
- W2017299012 cites W1965120630 @default.
- W2017299012 cites W1965710969 @default.
- W2017299012 cites W1965727970 @default.
- W2017299012 cites W1967383432 @default.
- W2017299012 cites W1967720741 @default.
- W2017299012 cites W1970850847 @default.
- W2017299012 cites W1971392719 @default.
- W2017299012 cites W1972689531 @default.
- W2017299012 cites W1973388854 @default.
- W2017299012 cites W1974466807 @default.
- W2017299012 cites W1975976700 @default.
- W2017299012 cites W1979022543 @default.
- W2017299012 cites W1979525972 @default.
- W2017299012 cites W1980991473 @default.
- W2017299012 cites W1981814215 @default.
- W2017299012 cites W1981924240 @default.
- W2017299012 cites W1983632012 @default.
- W2017299012 cites W1985496161 @default.
- W2017299012 cites W1987077580 @default.
- W2017299012 cites W1987784314 @default.
- W2017299012 cites W1989166415 @default.
- W2017299012 cites W1991658642 @default.
- W2017299012 cites W1991733505 @default.
- W2017299012 cites W1995082227 @default.
- W2017299012 cites W1995343246 @default.
- W2017299012 cites W1995744610 @default.
- W2017299012 cites W1996573346 @default.
- W2017299012 cites W2000899720 @default.
- W2017299012 cites W2001369445 @default.
- W2017299012 cites W2002363009 @default.
- W2017299012 cites W2003914797 @default.
- W2017299012 cites W2004762983 @default.
- W2017299012 cites W2005428052 @default.
- W2017299012 cites W2006752519 @default.
- W2017299012 cites W2007072099 @default.
- W2017299012 cites W2008843066 @default.
- W2017299012 cites W2011455194 @default.
- W2017299012 cites W2014118159 @default.
- W2017299012 cites W2014679097 @default.
- W2017299012 cites W2016471183 @default.
- W2017299012 cites W2016666792 @default.
- W2017299012 cites W2018675665 @default.
- W2017299012 cites W2021247853 @default.
- W2017299012 cites W2021477997 @default.
- W2017299012 cites W2021812810 @default.
- W2017299012 cites W2026270989 @default.
- W2017299012 cites W2027798990 @default.
- W2017299012 cites W2030086543 @default.
- W2017299012 cites W2031861778 @default.
- W2017299012 cites W2031952357 @default.
- W2017299012 cites W2032260378 @default.
- W2017299012 cites W2033022328 @default.
- W2017299012 cites W2033634633 @default.
- W2017299012 cites W2035865175 @default.
- W2017299012 cites W2040328933 @default.
- W2017299012 cites W2042194530 @default.
- W2017299012 cites W2043389398 @default.
- W2017299012 cites W2046783872 @default.
- W2017299012 cites W2047108248 @default.
- W2017299012 cites W2047495447 @default.
- W2017299012 cites W2050524172 @default.
- W2017299012 cites W2050914045 @default.
- W2017299012 cites W2050980507 @default.
- W2017299012 cites W2051240754 @default.
- W2017299012 cites W2053385942 @default.
- W2017299012 cites W2055577456 @default.
- W2017299012 cites W2056996834 @default.
- W2017299012 cites W2059276529 @default.
- W2017299012 cites W2060957604 @default.
- W2017299012 cites W2061356306 @default.
- W2017299012 cites W2062390081 @default.
- W2017299012 cites W2062700410 @default.
- W2017299012 cites W2062718835 @default.
- W2017299012 cites W2068163134 @default.
- W2017299012 cites W2069667445 @default.
- W2017299012 cites W2069753740 @default.
- W2017299012 cites W2069968649 @default.
- W2017299012 cites W2071089553 @default.
- W2017299012 cites W2071343804 @default.
- W2017299012 cites W2071895262 @default.
- W2017299012 cites W2073037264 @default.
- W2017299012 cites W2073204194 @default.
- W2017299012 cites W2077718608 @default.
- W2017299012 cites W2078559629 @default.