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• W2017302327 abstract "The dependence ofpaf-acether(paf)-induced human platelet activation on extracellular Ca2+ and Na+ was examined by quantitating aggregation, secretion and thromboxane (Tx) formation in the presence of physiological and/or low concentrations of Ca2+ and/or Na+. In the presence of 2mM Ca2+ and 140 mM Na+, paf induced a dose-dependent reversible aggregation and less than 25% of [14C]serotonin release. These responses were insensitive to aspirin or Tx antagonist SQ 29548 treatment and negligible amounts of Tx were formed. In low Ca2+ buffer, paf induced irreversible aggregation and the 14C-serotonin release could exceed 60%. These increases in platelet response were associated with the formation of Tx and were suppressed by aspirin and SQ 29548 treatments, or by substituting NaCI with N-methylglucamine hydrochloride. Thus, in low Ca2+ medium, Tx synthesis is favored during platelet activation and is dependent on Na+ concentrations. A decrease in extracellular Na+ inhibited the paf-acether-induced Tx synthesis observed in low Ca2+ medium but not that induced by the Tx direct precursor, arachidonic acid (AA). Therefore, the increase observed in low Ca2+ medium, no longer seen when the Na+ level is decreased is not related to an impairment of the cyclooxygenase activity but rather implicates an effect on the activity of phospholipase A2. A decrease in extracellular Na+ (2 mM Ca2+ present), inhibited [14C]serotonin release induced by paf from platelets which had, or had not been, treated with aspirin. In this medium, the AA-induced release reaction was also affected whereas Tx formation was not altered, thus suggesting that other mechanisms involved in platelet response apart from Tx synthesis are dependent on extracellular Na+." @default.
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• W2017302327 creator A5080194719 @default.
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• W2017302327 date "1989-10-01" @default.
• W2017302327 modified "2023-09-24" @default.
• W2017302327 title "The role of extracellular Ca2+ and Na+ in paf-acether-induced human platelet activation" @default.
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• W2017302327 doi "https://doi.org/10.1016/0006-2952(89)90109-3" @default.
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