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- W2017303390 abstract "This article is in essence a compilation of recent trace element studies of human tissue carried out by the Trace Metals Unit at Glasgow Royal Infirmary. The paper deals with the rationale behind the need for tissue analysis, sampling, sample preparation and choice of a frame of reference for reporting trace element concentrations in solid tissues. New multi-element techniques such as ICP:MS (Inductively Coupled Plasma Mass Spectrometry) are becoming available and we present evidence for the validity of results obtained by ICP:MS. The multi-element nature of ICP:MS leads naturally to an explosion of data (multi-variate data) which, although generally advantageous, is open to statistical abuse. This usually takes the form of repeated applications of a univariate test which in turn results in the generation of type 1 errors (i.e. false positives). These errors can be controlled in a variety of ways. In this article we have avoided the false positive by the application of the Bonferroni correction and also by the use of linear discriminant analysis. These statistical treatments both demonstrate that the young and the aged are different in their trace elemental composition. In another study we demonstrate that tissue taken from patients in chronic renal failure and treated by haemodialysis can accumulate higher concentrations of the toxic elements chromium and aluminium. The clinical significance of these accumulations have still to be determined." @default.
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- W2017303390 date "1992-01-01" @default.
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- W2017303390 title "Trace elements in autopsy tissue" @default.
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- W2017303390 doi "https://doi.org/10.1016/0308-8146(92)90217-p" @default.
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