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• W2017303933 endingPage "1138" @default.
• W2017303933 startingPage "1138" @default.
• W2017303933 abstract "Major depressive disorder (MDD) frequently emerges during adolescence and can lead to persistent illness, disability, and suicide. The maturational changes that take place in the brain during adolescence underscore the importance of examining neurobiological mechanisms during this time of early illness. However, neural mechanisms of depression in adolescents have been understudied. Research has implicated the amygdala in emotion processing in mood disorders, and adult depression studies have suggested amygdala-frontal connectivity deficits. Resting-state functional magnetic resonance imaging is an advanced tool that can be used to probe neural networks and identify brain-behavior relationships.To examine amygdala resting-state functional connectivity (RSFC) in adolescents with and without MDD using resting-state functional magnetic resonance imaging as well as how amygdala RSFC relates to a broad range of symptom dimensions.A cross-sectional resting-state functional magnetic resonance imaging study was conducted within a depression research program at an academic medical center. Participants included 41 adolescents and young adults aged 12 to 19 years with MDD and 29 healthy adolescents (frequency matched on age and sex) with no psychiatric diagnoses.Using a whole-brain functional connectivity approach, we examined the correlation of spontaneous fluctuation of the blood oxygen level-dependent signal of each voxel in the whole brain with that of the amygdala.Adolescents with MDD showed lower positive RSFC between the amygdala and hippocampus, parahippocampus, and brainstem (z >2.3, corrected P < .05); this connectivity was inversely correlated with general depression (R = -.523, P = .01), dysphoria (R = -.455, P = .05), and lassitude (R = -.449, P = .05) and was positively correlated with well-being (R = .470, P = .03). Patients also demonstrated greater (positive) amygdala-precuneus RSFC (z >2.3, corrected P < .05) in contrast to negative amygdala-precuneus RSFC in the adolescents serving as controls.Impaired amygdala-hippocampal/brainstem and amygdala-precuneus RSFC have not previously been highlighted in depression and may be unique to adolescent MDD. These circuits are important for different aspects of memory and self-processing and for modulation of physiologic responses to emotion. The findings suggest potential mechanisms underlying both mood and vegetative symptoms, potentially via impaired processing of memories and visceral signals that spontaneously arise during rest, contributing to the persistent symptoms experienced by adolescents with depression." @default.
• W2017303933 created "2016-06-24" @default.
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• W2017303933 date "2014-10-01" @default.
• W2017303933 modified "2023-10-17" @default.
• W2017303933 title "Abnormal Amygdala Resting-State Functional Connectivity in Adolescent Depression" @default.
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• W2017303933 cites W1665095741 @default.
• W2017303933 cites W1760829075 @default.
• W2017303933 cites W1965591468 @default.
• W2017303933 cites W1966326035 @default.
• W2017303933 cites W1969392677 @default.
• W2017303933 cites W1970006078 @default.
• W2017303933 cites W1971493062 @default.
• W2017303933 cites W1971685472 @default.
• W2017303933 cites W1973658723 @default.
• W2017303933 cites W1978267922 @default.
• W2017303933 cites W1983302342 @default.
• W2017303933 cites W1988273053 @default.
• W2017303933 cites W1990134753 @default.
• W2017303933 cites W1993053013 @default.
• W2017303933 cites W1998939912 @default.
• W2017303933 cites W2001307591 @default.
• W2017303933 cites W2009494091 @default.
• W2017303933 cites W2011140471 @default.
• W2017303933 cites W2026447783 @default.
• W2017303933 cites W2033802739 @default.
• W2017303933 cites W2037035617 @default.
• W2017303933 cites W2045970528 @default.
• W2017303933 cites W2046523960 @default.
• W2017303933 cites W2047751255 @default.
• W2017303933 cites W2047855968 @default.
• W2017303933 cites W2048254981 @default.
• W2017303933 cites W2048857243 @default.
• W2017303933 cites W2053540530 @default.
• W2017303933 cites W2054233890 @default.
• W2017303933 cites W2056102288 @default.
• W2017303933 cites W2063539434 @default.
• W2017303933 cites W2067294992 @default.
• W2017303933 cites W2068992432 @default.
• W2017303933 cites W2079117350 @default.
• W2017303933 cites W2082405250 @default.
• W2017303933 cites W2086026572 @default.
• W2017303933 cites W2087526026 @default.
• W2017303933 cites W2091005110 @default.
• W2017303933 cites W2094505237 @default.
• W2017303933 cites W2099292447 @default.
• W2017303933 cites W2106089606 @default.
• W2017303933 cites W2108582506 @default.
• W2017303933 cites W2109823330 @default.
• W2017303933 cites W2111613011 @default.
• W2017303933 cites W2120184832 @default.
• W2017303933 cites W2122384242 @default.
• W2017303933 cites W2123097685 @default.
• W2017303933 cites W2123442817 @default.
• W2017303933 cites W2123983635 @default.
• W2017303933 cites W2124141514 @default.
• W2017303933 cites W2129574992 @default.
• W2017303933 cites W2130960078 @default.
• W2017303933 cites W2134170969 @default.
• W2017303933 cites W2135147613 @default.
• W2017303933 cites W2138092999 @default.
• W2017303933 cites W2140798832 @default.
• W2017303933 cites W2142343279 @default.
• W2017303933 cites W2145103486 @default.
• W2017303933 cites W2145151017 @default.
• W2017303933 cites W2152292563 @default.
• W2017303933 cites W2153566421 @default.
• W2017303933 cites W2158056477 @default.
• W2017303933 cites W2158553737 @default.
• W2017303933 cites W2162010696 @default.
• W2017303933 cites W2165552226 @default.
• W2017303933 cites W2166523999 @default.
• W2017303933 cites W2166670920 @default.
• W2017303933 cites W2168372372 @default.
• W2017303933 cites W2169787465 @default.
• W2017303933 cites W2169793721 @default.
• W2017303933 cites W2254051562 @default.
• W2017303933 cites W2593832682 @default.
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• W2017303933 doi "https://doi.org/10.1001/jamapsychiatry.2014.1087" @default.
• W2017303933 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4378862" @default.
• W2017303933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25133665" @default.
• W2017303933 hasPublicationYear "2014" @default.
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