FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017307637> ?p ?o ?g. }

• W2017307637 endingPage "10931" @default.
• W2017307637 startingPage "10926" @default.
• W2017307637 abstract "Transcription networks composed of various transcriptional factors specifically expressed in undifferentiated embryonic stem (ES) cells have been implicated in the regulation of pluripotency in ES cells. However, the molecular mechanisms responsible for self-renewal, maintenance of pluripotency, and lineage specification during differentiation of ES cells are still unclear. The results of this study demonstrate that a phosphorylation-dependent chromatin relaxation factor, transcriptional intermediary factor–1β (TIF1β), is a unique regulator of the pluripotency of ES cells and regulates Oct3/4–dependent transcription in a phosphorylation-dependent manner. TIF1β is specifically phosphorylated in pluripotent mouse ES cells at the C-terminal serine 824, which has been previously shown to induce chromatin relaxation. Phosphorylated TIF1β is partially colocalized at the activated chromatin markers, and forms a complex with the pluripotency-specific transcription factor Oct3/4 and subunits of the switching defective/sucrose nonfermenting, ATP-dependent chromatin remodeling complex, Smarcad1, Brg-1, and BAF155, all of which are components of an ES-specific chromatin remodeling complex, esBAF. Phosphorylated TIF1β specifically induces ES cell–specific genes and enables prolonged main-tenance of an undifferentiated state in mouse ES cells. Moreover, TIF1β regulates the reprogramming process of somatic cells in a phosphorylation-dependent manner. Our results suggest that TIF1β provides a phosphorylation-dependent, bidirectional platform for specific transcriptional factors and chromatin remodeling enzymes that regulate the cell differentiation process and the pluripotency of stem cells." @default.
• W2017307637 created "2016-06-24" @default.
• W2017307637 creator A5001402212 @default.
• W2017307637 creator A5006296502 @default.
• W2017307637 creator A5043144221 @default.
• W2017307637 creator A5046870391 @default.
• W2017307637 creator A5048341713 @default.
• W2017307637 creator A5048793498 @default.
• W2017307637 creator A5074042042 @default.
• W2017307637 creator A5077595603 @default.
• W2017307637 creator A5079723083 @default.
• W2017307637 date "2010-05-27" @default.
• W2017307637 modified "2023-10-03" @default.
• W2017307637 title "TIF1β regulates the pluripotency of embryonic stem cells in a phosphorylation-dependent manner" @default.
• W2017307637 cites W1841489266 @default.
• W2017307637 cites W1900275723 @default.
• W2017307637 cites W1970774026 @default.
• W2017307637 cites W1981010326 @default.
• W2017307637 cites W2016691728 @default.
• W2017307637 cites W2031203839 @default.
• W2017307637 cites W2031496441 @default.
• W2017307637 cites W2036326229 @default.
• W2017307637 cites W2038249969 @default.
• W2017307637 cites W2038657349 @default.
• W2017307637 cites W2058521801 @default.
• W2017307637 cites W2065746091 @default.
• W2017307637 cites W2096857560 @default.
• W2017307637 cites W2098646008 @default.
• W2017307637 cites W2105073128 @default.
• W2017307637 cites W2105095718 @default.
• W2017307637 cites W2108451330 @default.
• W2017307637 cites W2109446392 @default.
• W2017307637 cites W2110707963 @default.
• W2017307637 cites W2111920812 @default.
• W2017307637 cites W2114900293 @default.
• W2017307637 cites W2117623697 @default.
• W2017307637 cites W2122215608 @default.
• W2017307637 cites W2125987139 @default.
• W2017307637 cites W2152652054 @default.
• W2017307637 cites W2162716784 @default.
• W2017307637 doi "https://doi.org/10.1073/pnas.0907601107" @default.
• W2017307637 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2890767" @default.
• W2017307637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20508149" @default.
• W2017307637 hasPublicationYear "2010" @default.
• W2017307637 type Work @default.
• W2017307637 sameAs 2017307637 @default.
• W2017307637 citedByCount "73" @default.
• W2017307637 countsByYear W20173076372012 @default.
• W2017307637 countsByYear W20173076372013 @default.
• W2017307637 countsByYear W20173076372014 @default.
• W2017307637 countsByYear W20173076372015 @default.
• W2017307637 countsByYear W20173076372016 @default.
• W2017307637 countsByYear W20173076372017 @default.
• W2017307637 countsByYear W20173076372018 @default.
• W2017307637 countsByYear W20173076372019 @default.
• W2017307637 countsByYear W20173076372020 @default.
• W2017307637 countsByYear W20173076372021 @default.
• W2017307637 countsByYear W20173076372022 @default.
• W2017307637 countsByYear W20173076372023 @default.
• W2017307637 crossrefType "journal-article" @default.
• W2017307637 hasAuthorship W2017307637A5001402212 @default.
• W2017307637 hasAuthorship W2017307637A5006296502 @default.
• W2017307637 hasAuthorship W2017307637A5043144221 @default.
• W2017307637 hasAuthorship W2017307637A5046870391 @default.
• W2017307637 hasAuthorship W2017307637A5048341713 @default.
• W2017307637 hasAuthorship W2017307637A5048793498 @default.
• W2017307637 hasAuthorship W2017307637A5074042042 @default.
• W2017307637 hasAuthorship W2017307637A5077595603 @default.
• W2017307637 hasAuthorship W2017307637A5079723083 @default.
• W2017307637 hasBestOaLocation W20173076372 @default.
• W2017307637 hasConcept C104317684 @default.
• W2017307637 hasConcept C107459253 @default.
• W2017307637 hasConcept C11960822 @default.
• W2017307637 hasConcept C134305767 @default.
• W2017307637 hasConcept C145103041 @default.
• W2017307637 hasConcept C148738053 @default.
• W2017307637 hasConcept C1491633281 @default.
• W2017307637 hasConcept C167227067 @default.
• W2017307637 hasConcept C28328180 @default.
• W2017307637 hasConcept C54355233 @default.
• W2017307637 hasConcept C77255625 @default.
• W2017307637 hasConcept C83640560 @default.
• W2017307637 hasConcept C86339819 @default.
• W2017307637 hasConcept C86803240 @default.
• W2017307637 hasConcept C95444343 @default.
• W2017307637 hasConceptScore W2017307637C104317684 @default.
• W2017307637 hasConceptScore W2017307637C107459253 @default.
• W2017307637 hasConceptScore W2017307637C11960822 @default.
• W2017307637 hasConceptScore W2017307637C134305767 @default.
• W2017307637 hasConceptScore W2017307637C145103041 @default.
• W2017307637 hasConceptScore W2017307637C148738053 @default.
• W2017307637 hasConceptScore W2017307637C1491633281 @default.
• W2017307637 hasConceptScore W2017307637C167227067 @default.
• W2017307637 hasConceptScore W2017307637C28328180 @default.
• W2017307637 hasConceptScore W2017307637C54355233 @default.
• W2017307637 hasConceptScore W2017307637C77255625 @default.
• W2017307637 hasConceptScore W2017307637C83640560 @default.
• W2017307637 hasConceptScore W2017307637C86339819 @default.

• next