Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017307672> ?p ?o ?g. }
- W2017307672 endingPage "348" @default.
- W2017307672 startingPage "337" @default.
- W2017307672 abstract "The type I interferon (IFN) family includes IFN-α, IFN-β, IFN-ϖ, and IFN-τ. These molecules are clustered according to sequence homologies, use of the same cell surface receptor, and similar functions. IFN-α and IFN-β have a globular structure composed of five a-helices. Their receptors, IFNAR1 and IFNAR2, belong to the class II cytokine receptor family for a-helical cytokines. Information about structure-function relationships between these and other IFNs is being provided by comparative sequence analysis, reference to a prototypic three-dimensional structure, analysis with monoclonal antibodies, construction of hybrid molecules and site directed mutagenesis. While much remains to be done, it should someday be possible to understand differences among IFNs in terms of how they interact with their corresponding receptors. Our recently identified IFN-like molecule, limitin, has weak sequence homology to IFN-α, IFN-β, and IFN-ω and displays its biological functions through the same IFN-α/β receptors. While limitin has antiproliferative, immunomodulatory, and antiviral effects like IFN-α and IFN-β, it is unique in lacking influence on myeloid and erythroid progenitors. Further analysis of this functionally unique cytokine should be informative about complex IFN–receptor interactions. Furthermore, a human homologue or synthetic variant might be superior for clinical applications as an IFN without myelosuppressive properties." @default.
- W2017307672 created "2016-06-24" @default.
- W2017307672 creator A5016982418 @default.
- W2017307672 creator A5073007367 @default.
- W2017307672 creator A5081091831 @default.
- W2017307672 creator A5086129270 @default.
- W2017307672 creator A5089639451 @default.
- W2017307672 date "2001-12-01" @default.
- W2017307672 modified "2023-10-11" @default.
- W2017307672 title "Type I interferons and limitin: a comparison of structures, receptors, and functions" @default.
- W2017307672 cites W104624952 @default.
- W2017307672 cites W1438571618 @default.
- W2017307672 cites W1498949169 @default.
- W2017307672 cites W1504251246 @default.
- W2017307672 cites W1504291265 @default.
- W2017307672 cites W1558675846 @default.
- W2017307672 cites W1562266462 @default.
- W2017307672 cites W1572190823 @default.
- W2017307672 cites W1586505650 @default.
- W2017307672 cites W1596176453 @default.
- W2017307672 cites W1597687278 @default.
- W2017307672 cites W1605500799 @default.
- W2017307672 cites W1605977136 @default.
- W2017307672 cites W1642082766 @default.
- W2017307672 cites W175910702 @default.
- W2017307672 cites W1769031535 @default.
- W2017307672 cites W1818602010 @default.
- W2017307672 cites W1867153422 @default.
- W2017307672 cites W1888326208 @default.
- W2017307672 cites W1906130994 @default.
- W2017307672 cites W1964684476 @default.
- W2017307672 cites W1977172773 @default.
- W2017307672 cites W1983639617 @default.
- W2017307672 cites W1985478627 @default.
- W2017307672 cites W1985929162 @default.
- W2017307672 cites W1985970958 @default.
- W2017307672 cites W1988496527 @default.
- W2017307672 cites W1991128945 @default.
- W2017307672 cites W1995946399 @default.
- W2017307672 cites W1996738224 @default.
- W2017307672 cites W1998238867 @default.
- W2017307672 cites W2000246573 @default.
- W2017307672 cites W2000844825 @default.
- W2017307672 cites W2001304636 @default.
- W2017307672 cites W2002376110 @default.
- W2017307672 cites W2004829503 @default.
- W2017307672 cites W2007245529 @default.
- W2017307672 cites W2011044131 @default.
- W2017307672 cites W2015198948 @default.
- W2017307672 cites W2015555315 @default.
- W2017307672 cites W2016779172 @default.
- W2017307672 cites W2018898580 @default.
- W2017307672 cites W2019697926 @default.
- W2017307672 cites W2021354063 @default.
- W2017307672 cites W2022075225 @default.
- W2017307672 cites W2026501903 @default.
- W2017307672 cites W2027025190 @default.
- W2017307672 cites W2037566429 @default.
- W2017307672 cites W2044135934 @default.
- W2017307672 cites W2053665669 @default.
- W2017307672 cites W2056366256 @default.
- W2017307672 cites W2059938714 @default.
- W2017307672 cites W2064962625 @default.
- W2017307672 cites W2065398995 @default.
- W2017307672 cites W2071837999 @default.
- W2017307672 cites W2079317094 @default.
- W2017307672 cites W2079373604 @default.
- W2017307672 cites W2080810100 @default.
- W2017307672 cites W2081124236 @default.
- W2017307672 cites W2081127519 @default.
- W2017307672 cites W2081350964 @default.
- W2017307672 cites W2088988430 @default.
- W2017307672 cites W2089033636 @default.
- W2017307672 cites W2091070578 @default.
- W2017307672 cites W2099674663 @default.
- W2017307672 cites W2101323431 @default.
- W2017307672 cites W2103069849 @default.
- W2017307672 cites W2106315019 @default.
- W2017307672 cites W2106319706 @default.
- W2017307672 cites W2112834292 @default.
- W2017307672 cites W2120171856 @default.
- W2017307672 cites W2122677373 @default.
- W2017307672 cites W2134743660 @default.
- W2017307672 cites W2135562155 @default.
- W2017307672 cites W2139332922 @default.
- W2017307672 cites W2145418572 @default.
- W2017307672 cites W2156947910 @default.
- W2017307672 cites W2157480451 @default.
- W2017307672 cites W2157642105 @default.
- W2017307672 cites W2177943720 @default.
- W2017307672 cites W2179862924 @default.
- W2017307672 cites W2199320236 @default.
- W2017307672 cites W2223236503 @default.
- W2017307672 cites W2313353292 @default.
- W2017307672 cites W2343499784 @default.
- W2017307672 cites W2465700633 @default.
- W2017307672 cites W2564590762 @default.
- W2017307672 cites W4240710787 @default.