FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017310059> ?p ?o ?g. }

• W2017310059 endingPage "151" @default.
• W2017310059 startingPage "141" @default.
• W2017310059 abstract "Paediatric inflammatory bowel disease (IBD), especially Crohn's disease (CD), is commonly associated with poor skeletal health, related to the direct effects of chronic inflammation, prolonged use of glucocorticoid (GC), poor nutrition, delayed puberty and low muscle mass. Low bone mineral density is commonly reported, although the prevalence of long bone fractures may not be increased in these patients. Emerging evidence however suggests that there may be an increased risk of vertebral fractures (VFs) in this group. VFs presenting at diagnosis of paediatric CD, prior to any GC exposure, have been reported, highlighting the deleterious effect of inflammation on skeletal health. This paper reviews the published literature on pathophysiology of skeletal morbidity and fractures in paediatric IBD, illustrated with a new case report of multiple VFs in a prepubertal girl with CD, soon after diagnosis, who received minimal amounts of oral GC. Optimising control of disease, addressing vitamin D deficiency, encouraging physical activity and ensuring normal growth and pubertal progression are paramount to management of bone health in these patients. Despite the lack of evidence, there may be a place for bisphosphonate treatment, especially in the presence of symptomatic pathological fractures, but this requires close monitoring by clinicians with expertise in paediatric bone health.Chronic inflammation mediated by pro-inflammatory cytokines may have adverse effects on skeletal health in paediatric patients with IBD. The risk of vertebral fractures may be increased, even without exposure to glucocorticoid. Clinical monitoring of these patients requires careful attention to the various factors that impact on bone health." @default.
• W2017310059 created "2016-06-24" @default.
• W2017310059 creator A5022951147 @default.
• W2017310059 creator A5047085949 @default.
• W2017310059 creator A5052663341 @default.
• W2017310059 date "2013-10-17" @default.
• W2017310059 modified "2023-10-01" @default.
• W2017310059 title "Pathological fractures in paediatric patients with inflammatory bowel disease" @default.
• W2017310059 cites W10184783 @default.
• W2017310059 cites W108551708 @default.
• W2017310059 cites W1597945029 @default.
• W2017310059 cites W1833610248 @default.
• W2017310059 cites W1892089875 @default.
• W2017310059 cites W1945180487 @default.
• W2017310059 cites W1966440512 @default.
• W2017310059 cites W1967910353 @default.
• W2017310059 cites W1971855336 @default.
• W2017310059 cites W1972549287 @default.
• W2017310059 cites W1976104827 @default.
• W2017310059 cites W1976915321 @default.
• W2017310059 cites W1979186513 @default.
• W2017310059 cites W1980418071 @default.
• W2017310059 cites W1982326982 @default.
• W2017310059 cites W1988186687 @default.
• W2017310059 cites W1994427645 @default.
• W2017310059 cites W1994509862 @default.
• W2017310059 cites W1995846491 @default.
• W2017310059 cites W1999966744 @default.
• W2017310059 cites W2000430896 @default.
• W2017310059 cites W2001635405 @default.
• W2017310059 cites W2002315967 @default.
• W2017310059 cites W2005376892 @default.
• W2017310059 cites W2006527175 @default.
• W2017310059 cites W2006567503 @default.
• W2017310059 cites W2012256930 @default.
• W2017310059 cites W2014067510 @default.
• W2017310059 cites W2014770452 @default.
• W2017310059 cites W2015694032 @default.
• W2017310059 cites W2020181500 @default.
• W2017310059 cites W2022998841 @default.
• W2017310059 cites W2024747603 @default.
• W2017310059 cites W2027953492 @default.
• W2017310059 cites W2028766716 @default.
• W2017310059 cites W2035511213 @default.
• W2017310059 cites W2036753188 @default.
• W2017310059 cites W2037426631 @default.
• W2017310059 cites W2037464255 @default.
• W2017310059 cites W2045697794 @default.
• W2017310059 cites W2051795199 @default.
• W2017310059 cites W2053648508 @default.
• W2017310059 cites W2055976513 @default.
• W2017310059 cites W2060076537 @default.
• W2017310059 cites W2060587883 @default.
• W2017310059 cites W2061279920 @default.
• W2017310059 cites W2063216829 @default.
• W2017310059 cites W2063674769 @default.
• W2017310059 cites W2064568108 @default.
• W2017310059 cites W2065578284 @default.
• W2017310059 cites W2069487594 @default.
• W2017310059 cites W2070991288 @default.
• W2017310059 cites W2076277955 @default.
• W2017310059 cites W2076448740 @default.
• W2017310059 cites W2076960105 @default.
• W2017310059 cites W2081039748 @default.
• W2017310059 cites W2084338700 @default.
• W2017310059 cites W2084827229 @default.
• W2017310059 cites W2087058051 @default.
• W2017310059 cites W2090911575 @default.
• W2017310059 cites W2091211366 @default.
• W2017310059 cites W2091335920 @default.
• W2017310059 cites W2091656394 @default.
• W2017310059 cites W2094500467 @default.
• W2017310059 cites W2095139297 @default.
• W2017310059 cites W2097391344 @default.
• W2017310059 cites W2102109825 @default.
• W2017310059 cites W2102523286 @default.
• W2017310059 cites W2105159474 @default.
• W2017310059 cites W2108362799 @default.
• W2017310059 cites W2112095609 @default.
• W2017310059 cites W2114961713 @default.
• W2017310059 cites W2114975770 @default.
• W2017310059 cites W2116082328 @default.
• W2017310059 cites W2119737749 @default.
• W2017310059 cites W2131023947 @default.
• W2017310059 cites W2131357215 @default.
• W2017310059 cites W2132511355 @default.
• W2017310059 cites W2132792165 @default.
• W2017310059 cites W2133275957 @default.
• W2017310059 cites W2136256187 @default.
• W2017310059 cites W2136966435 @default.
• W2017310059 cites W2139953697 @default.
• W2017310059 cites W2142656581 @default.
• W2017310059 cites W2146076762 @default.
• W2017310059 cites W2162279588 @default.
• W2017310059 cites W2163387216 @default.
• W2017310059 cites W2163820630 @default.
• W2017310059 cites W2164101170 @default.
• W2017310059 cites W2171278810 @default.

• next