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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017314474> ?p ?o ?g. }

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• W2017314474 abstract "Polycystic kidney disease (PKD), the most common genetic cause of chronic renal failure, is characterized by the presence of numerous fluid-filled cysts in renal parenchyma. Despite recent progress, no FDA-approved therapy is available to retard cyst growth. Here, we review current evidence implicating two groups of miRNAs - the miR-17~92 cluster and miR-200s - in the pathogenesis of PKD. We present a new hypothesis for cyst growth involving miRNAs and regulation of PKD gene dosage. We propose that manipulating miRNA function in an attempt to normalize PKD gene dosage represents a novel therapeutic strategy in PKD." @default.
• W2017314474 created "2016-06-24" @default.
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• W2017314474 date "2013-01-01" @default.
• W2017314474 modified "2023-09-24" @default.
• W2017314474 title "MicroRNAs and polycystic kidney disease" @default.
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• W2017314474 doi "https://doi.org/10.1016/j.ddmod.2013.10.001" @default.
• W2017314474 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4159181" @default.
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