FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017314950> ?p ?o ?g. }

• W2017314950 endingPage "14426" @default.
• W2017314950 startingPage "14415" @default.
• W2017314950 abstract "The serotonergic (5-HTergic) system arising from the dorsal raphe nucleus (DRN) is implicated in various physiological and behavioral processes, including stress responses. The DRN is comprised of several subnuclei, serving specific functions with distinct afferent and efferent connections. Furthermore, subsets of 5-HTergic neurons are known to coexpress other transmitters, including GABA, glutamate, or neuropeptides, thereby generating further heterogeneity. However, despite the growing evidence for functional variations among DRN subnuclei, relatively little is known about how they map onto neurochemical diversity of 5-HTergic neurons. In the present study, we characterized functional properties of GAD67-expressing 5-HTergic neurons (5-HT/GAD67 neurons) in the rat DRN, and compared with those of neurons expressing 5-HTergic molecules (5-HT neurons) or GAD67 alone. While 5-HT/GAD67 neurons were absent in the dorsomedial (DRD) or ventromedial (DRV) parts of the DRN, they were selectively distributed in the lateral wing of the DRN (DRL), constituting 12% of the total DRL neurons. They expressed plasmalemmal GABA transporter 1, but lacked vesicular inhibitory amino acid transporter. By using whole-cell patch-clamp recording, we found that 5-HT/GAD67 neurons had lower input resistance and firing frequency than 5-HT neurons. As revealed by c-Fos immunohistochemistry, neurons in the DRL, particularly 5-HT/GAD67 neurons, showed higher responsiveness to exposure to an open field arena than those in the DRD and DRV. By contrast, exposure to contextual fear conditioning stress showed no such regional differences. These findings indicate that 5-HT/GAD67 neurons constitute a unique neuronal population with distinctive neurochemical and electrophysiological properties and high responsiveness to innocuous stressor." @default.
• W2017314950 created "2016-06-24" @default.
• W2017314950 creator A5004433934 @default.
• W2017314950 creator A5017811687 @default.
• W2017314950 creator A5024316557 @default.
• W2017314950 creator A5050910269 @default.
• W2017314950 creator A5059868098 @default.
• W2017314950 creator A5063194937 @default.
• W2017314950 creator A5084262609 @default.
• W2017314950 creator A5091001168 @default.
• W2017314950 date "2012-10-10" @default.
• W2017314950 modified "2023-10-13" @default.
• W2017314950 title "Distinct Neurochemical and Functional Properties of GAD67-Containing 5-HT Neurons in the Rat Dorsal Raphe Nucleus" @default.
• W2017314950 cites W1505732106 @default.
• W2017314950 cites W1544500316 @default.
• W2017314950 cites W1564609481 @default.
• W2017314950 cites W1576110235 @default.
• W2017314950 cites W1828538530 @default.
• W2017314950 cites W1964219023 @default.
• W2017314950 cites W1964451838 @default.
• W2017314950 cites W1966384929 @default.
• W2017314950 cites W1968490089 @default.
• W2017314950 cites W1971472774 @default.
• W2017314950 cites W1974705547 @default.
• W2017314950 cites W1975355521 @default.
• W2017314950 cites W1976619257 @default.
• W2017314950 cites W1977283296 @default.
• W2017314950 cites W1988484809 @default.
• W2017314950 cites W1988939268 @default.
• W2017314950 cites W1989502651 @default.
• W2017314950 cites W1989900998 @default.
• W2017314950 cites W1990957877 @default.
• W2017314950 cites W1992392044 @default.
• W2017314950 cites W1999501421 @default.
• W2017314950 cites W1999965625 @default.
• W2017314950 cites W2003508747 @default.
• W2017314950 cites W2013404996 @default.
• W2017314950 cites W2017153246 @default.
• W2017314950 cites W2017463065 @default.
• W2017314950 cites W2026400531 @default.
• W2017314950 cites W2032089933 @default.
• W2017314950 cites W2036183103 @default.
• W2017314950 cites W2039725533 @default.
• W2017314950 cites W2040763671 @default.
• W2017314950 cites W2045043957 @default.
• W2017314950 cites W2051541361 @default.
• W2017314950 cites W2053720210 @default.
• W2017314950 cites W2053739364 @default.
• W2017314950 cites W2078172390 @default.
• W2017314950 cites W2078981560 @default.
• W2017314950 cites W2079169622 @default.
• W2017314950 cites W2083384830 @default.
• W2017314950 cites W2086748151 @default.
• W2017314950 cites W2087356150 @default.
• W2017314950 cites W2092554547 @default.
• W2017314950 cites W2099104826 @default.
• W2017314950 cites W2100548210 @default.
• W2017314950 cites W2100693671 @default.
• W2017314950 cites W2104210217 @default.
• W2017314950 cites W2115346246 @default.
• W2017314950 cites W2120039439 @default.
• W2017314950 cites W2123082568 @default.
• W2017314950 cites W2132593434 @default.
• W2017314950 cites W2134181051 @default.
• W2017314950 cites W2138455429 @default.
• W2017314950 cites W2139691325 @default.
• W2017314950 cites W2158404383 @default.
• W2017314950 cites W2332249202 @default.
• W2017314950 cites W2483623642 @default.
• W2017314950 doi "https://doi.org/10.1523/jneurosci.5929-11.2012" @default.
• W2017314950 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6622392" @default.
• W2017314950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23055511" @default.
• W2017314950 hasPublicationYear "2012" @default.
• W2017314950 type Work @default.
• W2017314950 sameAs 2017314950 @default.
• W2017314950 citedByCount "48" @default.
• W2017314950 countsByYear W20173149502012 @default.
• W2017314950 countsByYear W20173149502013 @default.
• W2017314950 countsByYear W20173149502014 @default.
• W2017314950 countsByYear W20173149502015 @default.
• W2017314950 countsByYear W20173149502016 @default.
• W2017314950 countsByYear W20173149502017 @default.
• W2017314950 countsByYear W20173149502018 @default.
• W2017314950 countsByYear W20173149502019 @default.
• W2017314950 countsByYear W20173149502020 @default.
• W2017314950 countsByYear W20173149502021 @default.
• W2017314950 countsByYear W20173149502022 @default.
• W2017314950 countsByYear W20173149502023 @default.
• W2017314950 crossrefType "journal-article" @default.
• W2017314950 hasAuthorship W2017314950A5004433934 @default.
• W2017314950 hasAuthorship W2017314950A5017811687 @default.
• W2017314950 hasAuthorship W2017314950A5024316557 @default.
• W2017314950 hasAuthorship W2017314950A5050910269 @default.
• W2017314950 hasAuthorship W2017314950A5059868098 @default.
• W2017314950 hasAuthorship W2017314950A5063194937 @default.
• W2017314950 hasAuthorship W2017314950A5084262609 @default.
• W2017314950 hasAuthorship W2017314950A5091001168 @default.
• W2017314950 hasBestOaLocation W20173149501 @default.

• next