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- W2017319667 abstract "Cleaning strategies have been evaluated for a microfiltration membrane fouled during cell harvesting. The membrane selected was a flat sheet of hydrophilic polyethersulphone with a nominal pore size of 0.1 μm. Baker’ s yeast was selected as a model micro-organism. During microfiltration, a constant transmembrane pressure of 2 bar, cross-flow velocity of 1ms−1, and suspension temperature of 34°C produced a steady state flux within 90 minutes. A water rinse removed the majority of the cellular cake revealing tenacious non-cellular and cellular deposits. Chemically enhanced cleaning of the rinsed deposit was investigated using dilute solutions of sodium hydroxide, nitric acid and P3 Ultrasil 11. Cleaning temperature effects were investigated over the range 30°C to 60°C and laminar and turbulent flow regimes were compared. A combination of measured flux recovery and microscopic visualization was used to assess cleaning performance. Effective two-stage cleaning was achieved with sequential alkali and acid treatments while effective single-stage cleaning was achieved using the formulated detergent P3 Ultrasil 11." @default.
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- W2017319667 date "1998-03-01" @default.
- W2017319667 modified "2023-09-24" @default.
- W2017319667 title "Membrane Cleaning: Chemically Enhanced Removal of Deposits Formed During Yeast Cell Harvesting" @default.
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- W2017319667 doi "https://doi.org/10.1205/096030898531729" @default.
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