Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017319763> ?p ?o ?g. }
- W2017319763 endingPage "97" @default.
- W2017319763 startingPage "77" @default.
- W2017319763 abstract "NAD(P)H:quinone oxidoreductase 1 (NQO1) is an obligate two-electron reductase that is involved in chemoprotection and can also bioactivate certain antitumor quinones. This review focuses on detoxification reactions catalyzed by NQO1 and its role in antioxidant defense via the generation of antioxidant forms of ubiquinone and vitamin E. Bioactivation reactions catalyzed by NQO1 are also summarized and the development of new antitumor agents for the therapy of solid tumors with marked NQO1 content is reviewed. NQO1 gene regulation and the role of the antioxidant response element and the xenobiotic response element in transcriptional regulation is summarized. An overview of genetic polymorphisms in NQO1 is presented and biological significance for chemoprotection, cancer susceptibility and antitumor drug action is discussed." @default.
- W2017319763 created "2016-06-24" @default.
- W2017319763 creator A5001448342 @default.
- W2017319763 creator A5014963329 @default.
- W2017319763 creator A5024622700 @default.
- W2017319763 creator A5026207971 @default.
- W2017319763 creator A5064269569 @default.
- W2017319763 creator A5076052578 @default.
- W2017319763 date "2000-12-01" @default.
- W2017319763 modified "2023-09-26" @default.
- W2017319763 title "NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms" @default.
- W2017319763 cites W1417333514 @default.
- W2017319763 cites W1481950549 @default.
- W2017319763 cites W1499795865 @default.
- W2017319763 cites W1551113005 @default.
- W2017319763 cites W1588470721 @default.
- W2017319763 cites W1595656597 @default.
- W2017319763 cites W1858268805 @default.
- W2017319763 cites W1914561217 @default.
- W2017319763 cites W1932522703 @default.
- W2017319763 cites W1964346504 @default.
- W2017319763 cites W1966014623 @default.
- W2017319763 cites W1966708809 @default.
- W2017319763 cites W1971090593 @default.
- W2017319763 cites W1972035122 @default.
- W2017319763 cites W1972441677 @default.
- W2017319763 cites W1972626671 @default.
- W2017319763 cites W1974684319 @default.
- W2017319763 cites W1975512386 @default.
- W2017319763 cites W1976141304 @default.
- W2017319763 cites W1976623065 @default.
- W2017319763 cites W1976725946 @default.
- W2017319763 cites W1977501799 @default.
- W2017319763 cites W1979578283 @default.
- W2017319763 cites W1980822546 @default.
- W2017319763 cites W1981751820 @default.
- W2017319763 cites W1982483359 @default.
- W2017319763 cites W1982805396 @default.
- W2017319763 cites W1984068492 @default.
- W2017319763 cites W1988206164 @default.
- W2017319763 cites W1989625861 @default.
- W2017319763 cites W1990780198 @default.
- W2017319763 cites W1990904896 @default.
- W2017319763 cites W1990927292 @default.
- W2017319763 cites W1991631628 @default.
- W2017319763 cites W1992346119 @default.
- W2017319763 cites W1993221979 @default.
- W2017319763 cites W1995894679 @default.
- W2017319763 cites W1997346441 @default.
- W2017319763 cites W1997469037 @default.
- W2017319763 cites W1999228082 @default.
- W2017319763 cites W2002314190 @default.
- W2017319763 cites W2002839475 @default.
- W2017319763 cites W2005813417 @default.
- W2017319763 cites W2008150054 @default.
- W2017319763 cites W2011822699 @default.
- W2017319763 cites W2014143515 @default.
- W2017319763 cites W2015687520 @default.
- W2017319763 cites W2021210557 @default.
- W2017319763 cites W2025039508 @default.
- W2017319763 cites W2026960884 @default.
- W2017319763 cites W2030524237 @default.
- W2017319763 cites W2030867249 @default.
- W2017319763 cites W2033274952 @default.
- W2017319763 cites W2036147144 @default.
- W2017319763 cites W2038795056 @default.
- W2017319763 cites W2045963619 @default.
- W2017319763 cites W2045965817 @default.
- W2017319763 cites W2046306533 @default.
- W2017319763 cites W2046567614 @default.
- W2017319763 cites W2047344689 @default.
- W2017319763 cites W2047955219 @default.
- W2017319763 cites W2048010533 @default.
- W2017319763 cites W2049768416 @default.
- W2017319763 cites W2050375436 @default.
- W2017319763 cites W2051841132 @default.
- W2017319763 cites W2053402235 @default.
- W2017319763 cites W2053536319 @default.
- W2017319763 cites W2053544423 @default.
- W2017319763 cites W2053831323 @default.
- W2017319763 cites W2054066025 @default.
- W2017319763 cites W2054330704 @default.
- W2017319763 cites W2054829241 @default.
- W2017319763 cites W2055277017 @default.
- W2017319763 cites W2058536932 @default.
- W2017319763 cites W2059395133 @default.
- W2017319763 cites W2060145043 @default.
- W2017319763 cites W2061081286 @default.
- W2017319763 cites W2062444423 @default.
- W2017319763 cites W2066170973 @default.
- W2017319763 cites W2066320805 @default.
- W2017319763 cites W2066363125 @default.
- W2017319763 cites W2066785941 @default.
- W2017319763 cites W2076412093 @default.
- W2017319763 cites W2079020117 @default.
- W2017319763 cites W2082481336 @default.
- W2017319763 cites W2085110243 @default.
- W2017319763 cites W2085403346 @default.