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• W2017321339 abstract "<b>Background:</b> Limbic encephalitis is a potentially treatable immunological condition. The presence of voltage-gated potassium channel antibodies (VGKC-Ab) in the cerebrospinal fluid (CSF) and serum of patients with the condition is a marker of the disease associated with a non-paraneoplastic form and good response to treatment. Recent work has highlighted absent serum VGKC-Ab and distinct immunology in patients with the paraneoplastic form of limbic encephalitis. <b>Methods:</b> The cases of four patients with the typical clinical presentation, neuropsychological features and brain imaging of acute limbic encephalitis, in the absence of any evidence for associated cancer during a follow-up of at least 18 months are described here. <b>Results:</b> All patients had negative testing for VGKC-Ab measured during their acute presentation. All patients made some recovery, although they were left with marked cognitive deficits and persistent seizures. <b>Conclusion:</b> These cases demonstrate that the absence of VGKC-Ab in limbic encephalitis does not necessarily imply a paraneoplastic form. Further work is required to establish the immunological basis for the disorder in these patients, and the optimal treatment regimen." @default.
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• W2017321339 date "2006-10-03" @default.
• W2017321339 modified "2023-10-18" @default.
• W2017321339 title "Course and outcome of acute limbic encephalitis with negative voltage-gated potassium channel antibodies" @default.
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• W2017321339 doi "https://doi.org/10.1136/jnnp.2006.093096" @default.
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