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• W2017321829 abstract "Aging and mortality is usually modeled by the Gompertz-Makeham distribution, where the mortality rate accelerates with age in adult humans. The resulting parameters are interpreted as the frailty and decrease in vitality with age. This fits well to life data from 'westernized' societies, where the data are accurate, of high resolution, and show the effects of high quality post-natal care. We show, however, that when the data are of lower resolution, and contain considerable structure in the infant mortality, the fit can be poor. Moreover, the Gompertz-Makeham distribution is consistent with neither the force of natural selection, nor the recently identified 'late life mortality deceleration'. Although actuarial models such as the Heligman-Pollard distribution can, in theory, achieve an improved fit, the lack of a closed form for the survival function makes fitting extremely arduous, and the biological interpretation can be lacking. We show, that a mixture, assigning mortality to exogenous or endogenous causes, using the reduced additive and flexible Weibull distributions, models well human mortality over the entire life span. The components of the mixture are asymptotically consistent with the reliability and biological theories of aging. The relative simplicity of the mixture distribution makes feasible a technique where the curvature functions of the corresponding survival and hazard rate functions are used to identify the beginning and the end of various life phases, such as infant mortality, the end of the force of natural selection, and late life mortality deceleration. We illustrate our results with a comparative analysis of Canadian and Indonesian mortality data." @default.
• W2017321829 created "2016-06-24" @default.
• W2017321829 creator A5005911653 @default.
• W2017321829 creator A5022957419 @default.
• W2017321829 creator A5033606159 @default.
• W2017321829 date "2007-04-01" @default.
• W2017321829 modified "2023-09-23" @default.
• W2017321829 title "Modeling human mortality using mixtures of bathtub shaped failure distributions" @default.
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• W2017321829 doi "https://doi.org/10.1016/j.jtbi.2006.11.011" @default.
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