FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017323382> ?p ?o ?g. }

• W2017323382 endingPage "8886" @default.
• W2017323382 startingPage "8876" @default.
• W2017323382 abstract "Neonates and infants are susceptible to infection due to distinct immune responses in early life. Therefore, development of vaccine formulation and delivery systems capable of activating human newborn leukocytes is of global health importance. Poly[di(carboxylatophenoxy)phosphazene] (PCPP) belongs to a family of ionic synthetic polyphosphazene polyelectrolyte compounds that can form non-covalent interactions with protein antigens and demonstrate adjuvant activity in animals and in human clinical trials. However, little is known about their ability to activate human immune cells. In this study, we characterized the effects of PCPP alone or in combination with a model antigen (recombinant HIV-Gag (Gag)), on the maturation, activation and antigen presentation by human adult and newborn dendritic cells (DCs) in vitro. PCPP treatment induced DC activation as assessed by upregulation of co-stimulatory molecules and cytokine production. Studies benchmarking PCPP to Alum, the most commonly used vaccine adjuvant, demonstrated that both triggered cell death and release of danger signals in adult and newborn DCs. When complexed with Gag antigen, PCPP maintained its immunostimulatory characteristics while permitting internalization and presentation of Gag by DCs to HIV-Gag-specific CD4+ T cell clones. The PCPP vaccine formulation outlined here has intrinsic adjuvant activity, can facilitate effective delivery of antigen to DCs, and may be advantageous for induction of beneficial T cell-mediated immunity. Moreover, polyphosphazenes can further reduce cost of vaccine production and distribution through their dose-sparing and antigen-stabilizing properties, thus potentially eliminating the need for cold chain distribution." @default.
• W2017323382 created "2016-06-24" @default.
• W2017323382 creator A5004023398 @default.
• W2017323382 creator A5018716429 @default.
• W2017323382 creator A5024157568 @default.
• W2017323382 creator A5051709565 @default.
• W2017323382 creator A5064784018 @default.
• W2017323382 creator A5068050214 @default.
• W2017323382 creator A5071685336 @default.
• W2017323382 creator A5076597576 @default.
• W2017323382 date "2014-10-01" @default.
• W2017323382 modified "2023-10-03" @default.
• W2017323382 title "The effect of stable macromolecular complexes of ionic polyphosphazene on HIV Gag antigen and on activation of human dendritic cells and presentation to T-cells" @default.
• W2017323382 cites W1550944704 @default.
• W2017323382 cites W1891826181 @default.
• W2017323382 cites W1968789597 @default.
• W2017323382 cites W1968972970 @default.
• W2017323382 cites W1970238011 @default.
• W2017323382 cites W1970898345 @default.
• W2017323382 cites W1972592756 @default.
• W2017323382 cites W1974136307 @default.
• W2017323382 cites W1976948056 @default.
• W2017323382 cites W1981099125 @default.
• W2017323382 cites W1982424442 @default.
• W2017323382 cites W1985117052 @default.
• W2017323382 cites W1985918025 @default.
• W2017323382 cites W1987044793 @default.
• W2017323382 cites W1993700308 @default.
• W2017323382 cites W2005830263 @default.
• W2017323382 cites W2009523990 @default.
• W2017323382 cites W2011115209 @default.
• W2017323382 cites W2012464349 @default.
• W2017323382 cites W2013652077 @default.
• W2017323382 cites W2029884055 @default.
• W2017323382 cites W2032942842 @default.
• W2017323382 cites W2034762448 @default.
• W2017323382 cites W2035782577 @default.
• W2017323382 cites W2042728718 @default.
• W2017323382 cites W2042926593 @default.
• W2017323382 cites W2061000745 @default.
• W2017323382 cites W2066068520 @default.
• W2017323382 cites W2068505576 @default.
• W2017323382 cites W2070416023 @default.
• W2017323382 cites W2072428961 @default.
• W2017323382 cites W2074766231 @default.
• W2017323382 cites W2076770240 @default.
• W2017323382 cites W2081354174 @default.
• W2017323382 cites W2082580360 @default.
• W2017323382 cites W2096258688 @default.
• W2017323382 cites W2106058187 @default.
• W2017323382 cites W2108476551 @default.
• W2017323382 cites W2115541182 @default.
• W2017323382 cites W2123912956 @default.
• W2017323382 cites W2133265454 @default.
• W2017323382 cites W2143146123 @default.
• W2017323382 cites W2144887013 @default.
• W2017323382 cites W2166556848 @default.
• W2017323382 cites W2244674613 @default.
• W2017323382 cites W4313331874 @default.
• W2017323382 doi "https://doi.org/10.1016/j.biomaterials.2014.06.043" @default.
• W2017323382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25023392" @default.
• W2017323382 hasPublicationYear "2014" @default.
• W2017323382 type Work @default.
• W2017323382 sameAs 2017323382 @default.
• W2017323382 citedByCount "30" @default.
• W2017323382 countsByYear W20173233822015 @default.
• W2017323382 countsByYear W20173233822016 @default.
• W2017323382 countsByYear W20173233822017 @default.
• W2017323382 countsByYear W20173233822018 @default.
• W2017323382 countsByYear W20173233822020 @default.
• W2017323382 countsByYear W20173233822021 @default.
• W2017323382 countsByYear W20173233822022 @default.
• W2017323382 crossrefType "journal-article" @default.
• W2017323382 hasAuthorship W2017323382A5004023398 @default.
• W2017323382 hasAuthorship W2017323382A5018716429 @default.
• W2017323382 hasAuthorship W2017323382A5024157568 @default.
• W2017323382 hasAuthorship W2017323382A5051709565 @default.
• W2017323382 hasAuthorship W2017323382A5064784018 @default.
• W2017323382 hasAuthorship W2017323382A5068050214 @default.
• W2017323382 hasAuthorship W2017323382A5071685336 @default.
• W2017323382 hasAuthorship W2017323382A5076597576 @default.
• W2017323382 hasConcept C108249834 @default.
• W2017323382 hasConcept C147483822 @default.
• W2017323382 hasConcept C185592680 @default.
• W2017323382 hasConcept C203014093 @default.
• W2017323382 hasConcept C2776090121 @default.
• W2017323382 hasConcept C2777863537 @default.
• W2017323382 hasConcept C2778170410 @default.
• W2017323382 hasConcept C67662055 @default.
• W2017323382 hasConcept C83464605 @default.
• W2017323382 hasConcept C86803240 @default.
• W2017323382 hasConcept C8891405 @default.
• W2017323382 hasConcept C95444343 @default.
• W2017323382 hasConceptScore W2017323382C108249834 @default.
• W2017323382 hasConceptScore W2017323382C147483822 @default.
• W2017323382 hasConceptScore W2017323382C185592680 @default.
• W2017323382 hasConceptScore W2017323382C203014093 @default.
• W2017323382 hasConceptScore W2017323382C2776090121 @default.

• next