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- W2017331311 abstract "By bioguided fractionation of the hexane extract of Commiphora erythraea resin we isolated four furanosesquiterpenoids that were tested for their protective activity against oxidative stress. Furanodienone and 1,10(15)-furanogermacra-dien-6-ones showed to be potent inhibitors of lipid peroxidation (IC50 of ~0.087 μM), being more active than the methoxylated analogues. Furthermore, using BV2 microglial cells, we found that furanodienone from C. erythraea is able to counteract LPS-induced cell death and decrease LPS-induced NO generation thus protecting microglial cells from LPS-induced cytotoxicity. Finally, docking studies were undertaken to gain insight into the possible binding mode of the isolated compounds at 5-LOX binding site." @default.
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- W2017331311 date "2011-12-14" @default.
- W2017331311 modified "2023-09-24" @default.
- W2017331311 title "Protective Effects of Commiphora erythraea Resin Constituents Against Cellular Oxidative Damage" @default.
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- W2017331311 doi "https://doi.org/10.3390/molecules161210357" @default.
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