Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017333363> ?p ?o ?g. }
- W2017333363 endingPage "393" @default.
- W2017333363 startingPage "377" @default.
- W2017333363 abstract "Keratinocyte growth factor (KGF) and its receptor KGFR play a pivotal role in regulating cell proliferation, migration, differentiation and survival, in response to injury and tissue repair. Altered expression of this pathway in cancer opened the way to the development of targeted therapy to achieve KGFR inhibition. Nevertheless, KGF administration has been demonstrated to ameliorate oral mucositis resulting from chemoradiotherapy, besides protecting epithelial cells against radiation-induced damage.This review focuses on the potential therapeutic interest of KGF/KGFR in two different areas: selective inhibition of KGFR signaling for the treatment of cancers characterized by upregulation of this pathway and administration of KGF to protect epithelial cells from induced damage. The review presents an overview of therapeutic strategies in both directions.KGF/KGFR signaling can contribute to enhancing the malignant potential of epithelial cells and to promoting tumorigenesis. On the other hand, the therapeutic use of KGF in cancer patients provides epithelial protection, reducing chemotherapy side effects. FGFRs have become attractive antitumor targets and various inhibitors have been used to contrast tumor cell growth. The identification of KGFR-specific molecules might represent a promising therapeutic strategy that could increase the window of available agents and treatment methods." @default.
- W2017333363 created "2016-06-24" @default.
- W2017333363 creator A5048666084 @default.
- W2017333363 creator A5054410590 @default.
- W2017333363 creator A5056031115 @default.
- W2017333363 creator A5075605378 @default.
- W2017333363 date "2012-03-25" @default.
- W2017333363 modified "2023-10-03" @default.
- W2017333363 title "Potential dual role of KGF/KGFR as a target option in novel therapeutic strategies for the treatment of cancers and mucosal damages" @default.
- W2017333363 cites W144423133 @default.
- W2017333363 cites W1537503588 @default.
- W2017333363 cites W1896753574 @default.
- W2017333363 cites W1937853139 @default.
- W2017333363 cites W1966159255 @default.
- W2017333363 cites W1972186163 @default.
- W2017333363 cites W1972688129 @default.
- W2017333363 cites W1973487236 @default.
- W2017333363 cites W1977447026 @default.
- W2017333363 cites W1978792905 @default.
- W2017333363 cites W1980266698 @default.
- W2017333363 cites W1980398407 @default.
- W2017333363 cites W1981643394 @default.
- W2017333363 cites W1983321673 @default.
- W2017333363 cites W1983803621 @default.
- W2017333363 cites W1984821767 @default.
- W2017333363 cites W1988476050 @default.
- W2017333363 cites W1992137373 @default.
- W2017333363 cites W1994664175 @default.
- W2017333363 cites W1994904788 @default.
- W2017333363 cites W1995306455 @default.
- W2017333363 cites W1998863388 @default.
- W2017333363 cites W2003445853 @default.
- W2017333363 cites W2004597141 @default.
- W2017333363 cites W2005992987 @default.
- W2017333363 cites W2006423274 @default.
- W2017333363 cites W2008153386 @default.
- W2017333363 cites W2008837727 @default.
- W2017333363 cites W2011009700 @default.
- W2017333363 cites W2011151090 @default.
- W2017333363 cites W2011415855 @default.
- W2017333363 cites W2013187395 @default.
- W2017333363 cites W2013773884 @default.
- W2017333363 cites W2016364458 @default.
- W2017333363 cites W2016396075 @default.
- W2017333363 cites W2016946888 @default.
- W2017333363 cites W2021108918 @default.
- W2017333363 cites W2024896457 @default.
- W2017333363 cites W2027150670 @default.
- W2017333363 cites W2027239974 @default.
- W2017333363 cites W2027317657 @default.
- W2017333363 cites W2028531522 @default.
- W2017333363 cites W2031541885 @default.
- W2017333363 cites W2042237248 @default.
- W2017333363 cites W2042545863 @default.
- W2017333363 cites W2044359179 @default.
- W2017333363 cites W2045165336 @default.
- W2017333363 cites W2047529648 @default.
- W2017333363 cites W2050328756 @default.
- W2017333363 cites W2052096807 @default.
- W2017333363 cites W2053388673 @default.
- W2017333363 cites W2054183022 @default.
- W2017333363 cites W2055172928 @default.
- W2017333363 cites W2055565205 @default.
- W2017333363 cites W2056512565 @default.
- W2017333363 cites W2056983875 @default.
- W2017333363 cites W2057048253 @default.
- W2017333363 cites W2057993685 @default.
- W2017333363 cites W2058370213 @default.
- W2017333363 cites W2059848983 @default.
- W2017333363 cites W2062233225 @default.
- W2017333363 cites W2063746351 @default.
- W2017333363 cites W2070815523 @default.
- W2017333363 cites W2072303535 @default.
- W2017333363 cites W2072787342 @default.
- W2017333363 cites W2074210527 @default.
- W2017333363 cites W2075329854 @default.
- W2017333363 cites W2075790601 @default.
- W2017333363 cites W2076906620 @default.
- W2017333363 cites W2080716137 @default.
- W2017333363 cites W2081558968 @default.
- W2017333363 cites W2083170353 @default.
- W2017333363 cites W2083906290 @default.
- W2017333363 cites W2085053752 @default.
- W2017333363 cites W2087693017 @default.
- W2017333363 cites W2093090488 @default.
- W2017333363 cites W2093204380 @default.
- W2017333363 cites W2096731324 @default.
- W2017333363 cites W2096861064 @default.
- W2017333363 cites W2096884232 @default.
- W2017333363 cites W2097557938 @default.
- W2017333363 cites W2097683496 @default.
- W2017333363 cites W2098637021 @default.
- W2017333363 cites W2098991939 @default.
- W2017333363 cites W2102174623 @default.
- W2017333363 cites W2102311237 @default.
- W2017333363 cites W2102894828 @default.
- W2017333363 cites W2103098489 @default.
- W2017333363 cites W2106838577 @default.