Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017334043> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2017334043 endingPage "263" @default.
- W2017334043 startingPage "253" @default.
- W2017334043 abstract "Summary Since homogeneous samples of insomniacs are difficult to recruit for pharmacotherapy studies, normal sleepers can be used to assess the protective effect of hypnotic drugs, under standardized nonconducive conditions. In particular, a noisy environment is a typical cause of situational insomnia that can be counteracted by a sedative-hypnotic agent. Six healthy middle-aged subjects (three men and three women), with no complaints about sleep, underwent a completely randomized double-blind series of 10 nocturnal polysomnograms with at least 72-h washout intervals. All subjects received a single dose of placebo, zolpidem 10 mg, zopiclone 7.5 mg, lorazepam 1 mg, and triazolam 0.25 mg both under basal and under perturbed conditions. For each individual, five recordings were carried out under basal conditions (sound pressure level not higher than 30 dB) and five recordings under acoustically perturbed conditions (continuous white noise at 55 dB). Sleep quality was assessed by means of a visual analogue scale (VAS). All recordings were scored according to conventional rules (macrostructure) and cyclic alternating pattern (CAP) methodology (microstructure). Statistical analysis was based on a repeated measures analysis-of-variance design integrated by Bonferroni adjusted probabilities. Under placebo, situational insomnia was confirmed by the significant increase in sleep fragmentation (intra-sleep wakefulness) and by the significant enhancement of arousal instability (CAP parameters). In contrast to macrostructural information, CAP parameters were highly sensitive in detecting the perturbing effects of noise (mean CAP rate under placebo, 57%) and the protective action of hypnotic drugs during perturbation (mean CAP rate under active medication, 41%). Microstructural analysis enabled us to discriminate hypnotic drugs from placebo, nonbenzodiazepine compounds from benzodiazepine agents, and zopiclone from zolpidem. The latter, in fact, induced the lowest values of CAP rate both under basal (30%) and under noisy (39%) conditions and determined a significant decrease in ±" @default.
- W2017334043 created "2016-06-24" @default.
- W2017334043 creator A5005344544 @default.
- W2017334043 creator A5014698141 @default.
- W2017334043 creator A5056488945 @default.
- W2017334043 creator A5064970802 @default.
- W2017334043 creator A5086778935 @default.
- W2017334043 date "1997-06-01" @default.
- W2017334043 modified "2023-10-03" @default.
- W2017334043 title "Multidrug Comparison (Lorazepam, Triazolam, Zolpidem, and Zopiclone) in Situational Insomnia" @default.
- W2017334043 doi "https://doi.org/10.1097/00002826-199706000-00010" @default.
- W2017334043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9197949" @default.
- W2017334043 hasPublicationYear "1997" @default.
- W2017334043 type Work @default.
- W2017334043 sameAs 2017334043 @default.
- W2017334043 citedByCount "62" @default.
- W2017334043 countsByYear W20173340432012 @default.
- W2017334043 countsByYear W20173340432013 @default.
- W2017334043 countsByYear W20173340432014 @default.
- W2017334043 countsByYear W20173340432015 @default.
- W2017334043 countsByYear W20173340432016 @default.
- W2017334043 countsByYear W20173340432017 @default.
- W2017334043 countsByYear W20173340432019 @default.
- W2017334043 countsByYear W20173340432021 @default.
- W2017334043 countsByYear W20173340432023 @default.
- W2017334043 crossrefType "journal-article" @default.
- W2017334043 hasAuthorship W2017334043A5005344544 @default.
- W2017334043 hasAuthorship W2017334043A5014698141 @default.
- W2017334043 hasAuthorship W2017334043A5056488945 @default.
- W2017334043 hasAuthorship W2017334043A5064970802 @default.
- W2017334043 hasAuthorship W2017334043A5086778935 @default.
- W2017334043 hasConcept C118552586 @default.
- W2017334043 hasConcept C126322002 @default.
- W2017334043 hasConcept C142724271 @default.
- W2017334043 hasConcept C15744967 @default.
- W2017334043 hasConcept C170493617 @default.
- W2017334043 hasConcept C204787440 @default.
- W2017334043 hasConcept C27081682 @default.
- W2017334043 hasConcept C2777123777 @default.
- W2017334043 hasConcept C2777602617 @default.
- W2017334043 hasConcept C2777810057 @default.
- W2017334043 hasConcept C2778173252 @default.
- W2017334043 hasConcept C2779706987 @default.
- W2017334043 hasConcept C2779738154 @default.
- W2017334043 hasConcept C2780930544 @default.
- W2017334043 hasConcept C2781210498 @default.
- W2017334043 hasConcept C42219234 @default.
- W2017334043 hasConcept C548259974 @default.
- W2017334043 hasConcept C71924100 @default.
- W2017334043 hasConceptScore W2017334043C118552586 @default.
- W2017334043 hasConceptScore W2017334043C126322002 @default.
- W2017334043 hasConceptScore W2017334043C142724271 @default.
- W2017334043 hasConceptScore W2017334043C15744967 @default.
- W2017334043 hasConceptScore W2017334043C170493617 @default.
- W2017334043 hasConceptScore W2017334043C204787440 @default.
- W2017334043 hasConceptScore W2017334043C27081682 @default.
- W2017334043 hasConceptScore W2017334043C2777123777 @default.
- W2017334043 hasConceptScore W2017334043C2777602617 @default.
- W2017334043 hasConceptScore W2017334043C2777810057 @default.
- W2017334043 hasConceptScore W2017334043C2778173252 @default.
- W2017334043 hasConceptScore W2017334043C2779706987 @default.
- W2017334043 hasConceptScore W2017334043C2779738154 @default.
- W2017334043 hasConceptScore W2017334043C2780930544 @default.
- W2017334043 hasConceptScore W2017334043C2781210498 @default.
- W2017334043 hasConceptScore W2017334043C42219234 @default.
- W2017334043 hasConceptScore W2017334043C548259974 @default.
- W2017334043 hasConceptScore W2017334043C71924100 @default.
- W2017334043 hasIssue "3" @default.
- W2017334043 hasLocation W20173340431 @default.
- W2017334043 hasLocation W20173340432 @default.
- W2017334043 hasOpenAccess W2017334043 @default.
- W2017334043 hasPrimaryLocation W20173340431 @default.
- W2017334043 hasRelatedWork W2007828840 @default.
- W2017334043 hasRelatedWork W2017334043 @default.
- W2017334043 hasRelatedWork W2023116661 @default.
- W2017334043 hasRelatedWork W2035250490 @default.
- W2017334043 hasRelatedWork W2040290595 @default.
- W2017334043 hasRelatedWork W2092946324 @default.
- W2017334043 hasRelatedWork W2740526505 @default.
- W2017334043 hasRelatedWork W3214172370 @default.
- W2017334043 hasRelatedWork W4231339354 @default.
- W2017334043 hasRelatedWork W4240005720 @default.
- W2017334043 hasVolume "20" @default.
- W2017334043 isParatext "false" @default.
- W2017334043 isRetracted "false" @default.
- W2017334043 magId "2017334043" @default.
- W2017334043 workType "article" @default.