FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017335958> ?p ?o ?g. }

• W2017335958 endingPage "20" @default.
• W2017335958 startingPage "1" @default.
• W2017335958 abstract "The past decade has seen a fundamental reappraisal of the protein structure-to-function paradigm because it became evident that a significant fraction of polypeptides are lacking ordered structures under physiological conditions. Ligand-induced disorder-to-order transition plays a key role in the biological functions of many proteins that contain intrinsically disordered regions. This trait is exhibited by RTX (Repeat in ToXin) motifs found in more than 250 virulence factors secreted by Gram-negative pathogenic bacteria. We have investigated several RTX-containing polypeptides of different lengths, all derived from the Bordetella pertussis adenylate cyclase toxin, CyaA. Using a combination of experimental approaches, we showed that the RTX proteins exhibit the hallmarks of intrinsically disordered proteins in the absence of calcium. This intrinsic disorder mainly results from internal electrostatic repulsions between negatively charged residues of the RTX motifs. Calcium binding triggers a strong reduction of the mean net charge, dehydration and compaction, folding and stabilization of secondary and tertiary structures of the RTX proteins. We propose that the intrinsically disordered character of the RTX proteins may facilitate the uptake and secretion of virulence factors through the bacterial secretion machinery. These results support the hypothesis that the folding reaction is achieved upon protein secretion and, in the case of proteins containing RTX motifs, could be finely regulated by the calcium gradient across bacterial cell wall." @default.
• W2017335958 created "2016-06-24" @default.
• W2017335958 creator A5012650088 @default.
• W2017335958 creator A5033784871 @default.
• W2017335958 creator A5040126899 @default.
• W2017335958 date "2014-12-31" @default.
• W2017335958 modified "2023-10-10" @default.
• W2017335958 title "Disorder-to-Order Transition in the CyaA Toxin RTX Domain: Implications for Toxin Secretion" @default.
• W2017335958 cites W1487053853 @default.
• W2017335958 cites W1586520658 @default.
• W2017335958 cites W1720678970 @default.
• W2017335958 cites W1892292145 @default.
• W2017335958 cites W1911914363 @default.
• W2017335958 cites W1968685804 @default.
• W2017335958 cites W1976444772 @default.
• W2017335958 cites W1977069949 @default.
• W2017335958 cites W1983557956 @default.
• W2017335958 cites W1989073611 @default.
• W2017335958 cites W1991032846 @default.
• W2017335958 cites W1992363272 @default.
• W2017335958 cites W1992655510 @default.
• W2017335958 cites W1996072101 @default.
• W2017335958 cites W1997052610 @default.
• W2017335958 cites W1998312671 @default.
• W2017335958 cites W1998494984 @default.
• W2017335958 cites W2002570849 @default.
• W2017335958 cites W2004023386 @default.
• W2017335958 cites W2008494223 @default.
• W2017335958 cites W2011127667 @default.
• W2017335958 cites W2013621401 @default.
• W2017335958 cites W2020606589 @default.
• W2017335958 cites W2020861700 @default.
• W2017335958 cites W2022959668 @default.
• W2017335958 cites W2023752536 @default.
• W2017335958 cites W2024721194 @default.
• W2017335958 cites W2028129929 @default.
• W2017335958 cites W2036846779 @default.
• W2017335958 cites W2039702018 @default.
• W2017335958 cites W2040252169 @default.
• W2017335958 cites W2042451397 @default.
• W2017335958 cites W2044636054 @default.
• W2017335958 cites W2046499903 @default.
• W2017335958 cites W2053561688 @default.
• W2017335958 cites W2072850443 @default.
• W2017335958 cites W2081843165 @default.
• W2017335958 cites W2085901954 @default.
• W2017335958 cites W2089039697 @default.
• W2017335958 cites W2092886566 @default.
• W2017335958 cites W2104161116 @default.
• W2017335958 cites W2109045926 @default.
• W2017335958 cites W2111433307 @default.
• W2017335958 cites W2114823344 @default.
• W2017335958 cites W2119827607 @default.
• W2017335958 cites W2128890194 @default.
• W2017335958 cites W2132720084 @default.
• W2017335958 cites W2142522096 @default.
• W2017335958 cites W2145383898 @default.
• W2017335958 cites W2172154503 @default.
• W2017335958 cites W2312993206 @default.
• W2017335958 cites W2412063897 @default.
• W2017335958 cites W2472889759 @default.
• W2017335958 cites W4250187604 @default.
• W2017335958 cites W43726920 @default.
• W2017335958 doi "https://doi.org/10.3390/toxins7010001" @default.
• W2017335958 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4303809" @default.
• W2017335958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25559101" @default.
• W2017335958 hasPublicationYear "2014" @default.
• W2017335958 type Work @default.
• W2017335958 sameAs 2017335958 @default.
• W2017335958 citedByCount "33" @default.
• W2017335958 countsByYear W20173359582015 @default.
• W2017335958 countsByYear W20173359582016 @default.
• W2017335958 countsByYear W20173359582017 @default.
• W2017335958 countsByYear W20173359582018 @default.
• W2017335958 countsByYear W20173359582019 @default.
• W2017335958 countsByYear W20173359582020 @default.
• W2017335958 countsByYear W20173359582021 @default.
• W2017335958 countsByYear W20173359582022 @default.
• W2017335958 crossrefType "journal-article" @default.
• W2017335958 hasAuthorship W2017335958A5012650088 @default.
• W2017335958 hasAuthorship W2017335958A5033784871 @default.
• W2017335958 hasAuthorship W2017335958A5040126899 @default.
• W2017335958 hasBestOaLocation W20173359581 @default.
• W2017335958 hasConcept C104317684 @default.
• W2017335958 hasConcept C12554922 @default.
• W2017335958 hasConcept C185592680 @default.
• W2017335958 hasConcept C204328495 @default.
• W2017335958 hasConcept C2777367657 @default.
• W2017335958 hasConcept C2777582894 @default.
• W2017335958 hasConcept C2910325308 @default.
• W2017335958 hasConcept C49039625 @default.
• W2017335958 hasConcept C49773422 @default.
• W2017335958 hasConcept C523546767 @default.
• W2017335958 hasConcept C54355233 @default.
• W2017335958 hasConcept C55493867 @default.
• W2017335958 hasConcept C60987743 @default.
• W2017335958 hasConcept C62478195 @default.
• W2017335958 hasConcept C80631254 @default.

• next