FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017338209> ?p ?o ?g. }

• W2017338209 endingPage "43133" @default.
• W2017338209 startingPage "43123" @default.
• W2017338209 abstract "Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis through binding to TRAIL receptors, death receptor 4 (DR4), and DR5. TRAIL has potential therapeutic value against cancer because of its selective cytotoxic effects on several transformed cell types. Fucosylation of proteins and lipids on the cell surface is a very important posttranslational modification that is involved in many cellular events. Recently, we found that a deficiency in GDP-mannose-4,6-dehydratase (GMDS) rendered colon cancer cells resistant to TRAIL-induced apoptosis, resulting in tumor development and metastasis by escape from tumor immune surveillance. GMDS is an indispensable regulator of cellular fucosylation. In this study, we investigated the molecular mechanism of inhibition of TRAIL signaling by GMDS deficiency. DR4, but not DR5, was found to be fucosylated; however, GMDS deficiency inhibited both DR4- and DR5-mediated apoptosis despite the absence of fucosylation on DR5. In addition, GMDS deficiency also inhibited CD95-mediated apoptosis but not the intrinsic apoptosis pathway induced by anti-cancer drugs. Binding of TRAIL and CD95 ligand to their cognate receptors primarily leads to formation of a complex comprising the receptor, FADD, and caspase-8, referred to as the death-inducing signaling complex (DISC). GMDS deficiency did not affect formation of the primary DISC or recruitment to and activation of caspase-8 on the DISC. However, formation of secondary FADD-dependent complex II, comprising caspase-8 and cFLIP, was significantly inhibited by GMDS deficiency. These results indicate that GMDS regulates the formation of secondary complex II from the primary DISC independent of direct fucosylation of death receptors." @default.
• W2017338209 created "2016-06-24" @default.
• W2017338209 creator A5029088191 @default.
• W2017338209 creator A5047938943 @default.
• W2017338209 creator A5080369708 @default.
• W2017338209 date "2011-12-01" @default.
• W2017338209 modified "2023-09-26" @default.
• W2017338209 title "GDP-mannose-4,6-dehydratase (GMDS) Deficiency Renders Colon Cancer Cells Resistant to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Receptor- and CD95-mediated Apoptosis by Inhibiting Complex II Formation" @default.
• W2017338209 cites W1528349069 @default.
• W2017338209 cites W1973792489 @default.
• W2017338209 cites W1987506447 @default.
• W2017338209 cites W1994653208 @default.
• W2017338209 cites W1994874844 @default.
• W2017338209 cites W1996840415 @default.
• W2017338209 cites W2016345107 @default.
• W2017338209 cites W2016417780 @default.
• W2017338209 cites W2019664231 @default.
• W2017338209 cites W2022190919 @default.
• W2017338209 cites W2026380980 @default.
• W2017338209 cites W2034071655 @default.
• W2017338209 cites W2034993166 @default.
• W2017338209 cites W2038118195 @default.
• W2017338209 cites W2039805273 @default.
• W2017338209 cites W2047390867 @default.
• W2017338209 cites W2047972729 @default.
• W2017338209 cites W2058681712 @default.
• W2017338209 cites W2059799534 @default.
• W2017338209 cites W2069875612 @default.
• W2017338209 cites W2075809552 @default.
• W2017338209 cites W2077903565 @default.
• W2017338209 cites W2088434373 @default.
• W2017338209 cites W2096443169 @default.
• W2017338209 cites W2101168190 @default.
• W2017338209 cites W2114727688 @default.
• W2017338209 cites W2117692326 @default.
• W2017338209 cites W2117946498 @default.
• W2017338209 cites W2118971842 @default.
• W2017338209 cites W2119239083 @default.
• W2017338209 cites W2124992697 @default.
• W2017338209 cites W2134706781 @default.
• W2017338209 cites W2135275878 @default.
• W2017338209 cites W2137686679 @default.
• W2017338209 cites W2152653388 @default.
• W2017338209 cites W2152807226 @default.
• W2017338209 doi "https://doi.org/10.1074/jbc.m111.262741" @default.
• W2017338209 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3234837" @default.
• W2017338209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22027835" @default.
• W2017338209 hasPublicationYear "2011" @default.
• W2017338209 type Work @default.
• W2017338209 sameAs 2017338209 @default.
• W2017338209 citedByCount "39" @default.
• W2017338209 countsByYear W20173382092012 @default.
• W2017338209 countsByYear W20173382092013 @default.
• W2017338209 countsByYear W20173382092014 @default.
• W2017338209 countsByYear W20173382092015 @default.
• W2017338209 countsByYear W20173382092016 @default.
• W2017338209 countsByYear W20173382092017 @default.
• W2017338209 countsByYear W20173382092018 @default.
• W2017338209 countsByYear W20173382092019 @default.
• W2017338209 countsByYear W20173382092020 @default.
• W2017338209 countsByYear W20173382092021 @default.
• W2017338209 countsByYear W20173382092022 @default.
• W2017338209 countsByYear W20173382092023 @default.
• W2017338209 crossrefType "journal-article" @default.
• W2017338209 hasAuthorship W2017338209A5029088191 @default.
• W2017338209 hasAuthorship W2017338209A5047938943 @default.
• W2017338209 hasAuthorship W2017338209A5080369708 @default.
• W2017338209 hasBestOaLocation W20173382091 @default.
• W2017338209 hasConcept C108625454 @default.
• W2017338209 hasConcept C121608353 @default.
• W2017338209 hasConcept C170493617 @default.
• W2017338209 hasConcept C17991360 @default.
• W2017338209 hasConcept C185592680 @default.
• W2017338209 hasConcept C190283241 @default.
• W2017338209 hasConcept C203014093 @default.
• W2017338209 hasConcept C2776055636 @default.
• W2017338209 hasConcept C2776841590 @default.
• W2017338209 hasConcept C2779212266 @default.
• W2017338209 hasConcept C2908803906 @default.
• W2017338209 hasConcept C3031857 @default.
• W2017338209 hasConcept C31573885 @default.
• W2017338209 hasConcept C48297814 @default.
• W2017338209 hasConcept C502942594 @default.
• W2017338209 hasConcept C54355233 @default.
• W2017338209 hasConcept C55493867 @default.
• W2017338209 hasConcept C62478195 @default.
• W2017338209 hasConcept C86803240 @default.
• W2017338209 hasConcept C95444343 @default.
• W2017338209 hasConcept C96232424 @default.
• W2017338209 hasConcept C98424977 @default.
• W2017338209 hasConceptScore W2017338209C108625454 @default.
• W2017338209 hasConceptScore W2017338209C121608353 @default.
• W2017338209 hasConceptScore W2017338209C170493617 @default.
• W2017338209 hasConceptScore W2017338209C17991360 @default.
• W2017338209 hasConceptScore W2017338209C185592680 @default.
• W2017338209 hasConceptScore W2017338209C190283241 @default.
• W2017338209 hasConceptScore W2017338209C203014093 @default.
• W2017338209 hasConceptScore W2017338209C2776055636 @default.

• next