Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017339304> ?p ?o ?g. }
- W2017339304 endingPage "66" @default.
- W2017339304 startingPage "61" @default.
- W2017339304 abstract "β-Adrenoceptor antagonists are known to increase plasma atrial natriuretic peptide (ANP) levels despite their hypotensive action. The aim of the present study was to examine the role of the ANP system in the antihypertensive effects of a β-adrenoceptor antagonist. We investigated the effects of propranolol (75 mg kg−1 day−1, p.o., 4 weeks) on the ANP system in stroke-prone spontaneously hypertensive rats. Plasma ANP levels were significantly higher in the propranolol group than in the control group. Both receptor densities and mRNA levels of ANPC receptor were significantly decreased in the lung as the major site of ANP clearance from the circulation. In contrast, both central venous pressure and ANP mRNA levels in the heart were not significantly different between the two groups. Under both basal and ANP-stimulated conditions, the cGMP content in the aorta was significantly greater in the propranolol group than in the control group, whereas the basal and stimulated cGMP content of the kidney was similar in the two groups. Inhibition of endogenous ANP action by a specific ANP receptor antagonist, HS-142-1, produced a greater increase of blood pressure in the propranolol group than in the control group. These results suggest potentiation of natriuretic peptide activity as a new antihypertensive mechanism of the β-adrenoceptor antagonist propranolol." @default.
- W2017339304 created "2016-06-24" @default.
- W2017339304 creator A5011105044 @default.
- W2017339304 creator A5012387869 @default.
- W2017339304 creator A5017193469 @default.
- W2017339304 creator A5030293363 @default.
- W2017339304 creator A5041743524 @default.
- W2017339304 creator A5046482075 @default.
- W2017339304 creator A5059254858 @default.
- W2017339304 creator A5065053580 @default.
- W2017339304 creator A5075757845 @default.
- W2017339304 creator A5087348549 @default.
- W2017339304 creator A5090348913 @default.
- W2017339304 date "1998-06-01" @default.
- W2017339304 modified "2023-09-27" @default.
- W2017339304 title "β-Adrenoceptor antagonist propranolol potentiates hypotensive action of natriuretic peptides" @default.
- W2017339304 cites W1542279315 @default.
- W2017339304 cites W1593231964 @default.
- W2017339304 cites W1606294561 @default.
- W2017339304 cites W2007281605 @default.
- W2017339304 cites W2011113889 @default.
- W2017339304 cites W2012849996 @default.
- W2017339304 cites W2013334996 @default.
- W2017339304 cites W2038305939 @default.
- W2017339304 cites W2043492462 @default.
- W2017339304 cites W2051743630 @default.
- W2017339304 cites W2054649519 @default.
- W2017339304 cites W2063400688 @default.
- W2017339304 cites W2065531704 @default.
- W2017339304 cites W2070996706 @default.
- W2017339304 cites W2088440519 @default.
- W2017339304 cites W2103897701 @default.
- W2017339304 cites W2119455028 @default.
- W2017339304 cites W2138391109 @default.
- W2017339304 cites W2141935051 @default.
- W2017339304 cites W2145117388 @default.
- W2017339304 cites W4233683131 @default.
- W2017339304 cites W4236618345 @default.
- W2017339304 cites W4240493000 @default.
- W2017339304 cites W4248518757 @default.
- W2017339304 cites W4294216491 @default.
- W2017339304 cites W81844788 @default.
- W2017339304 doi "https://doi.org/10.1016/s0014-2999(98)00291-x" @default.
- W2017339304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9698206" @default.
- W2017339304 hasPublicationYear "1998" @default.
- W2017339304 type Work @default.
- W2017339304 sameAs 2017339304 @default.
- W2017339304 citedByCount "13" @default.
- W2017339304 crossrefType "journal-article" @default.
- W2017339304 hasAuthorship W2017339304A5011105044 @default.
- W2017339304 hasAuthorship W2017339304A5012387869 @default.
- W2017339304 hasAuthorship W2017339304A5017193469 @default.
- W2017339304 hasAuthorship W2017339304A5030293363 @default.
- W2017339304 hasAuthorship W2017339304A5041743524 @default.
- W2017339304 hasAuthorship W2017339304A5046482075 @default.
- W2017339304 hasAuthorship W2017339304A5059254858 @default.
- W2017339304 hasAuthorship W2017339304A5065053580 @default.
- W2017339304 hasAuthorship W2017339304A5075757845 @default.
- W2017339304 hasAuthorship W2017339304A5087348549 @default.
- W2017339304 hasAuthorship W2017339304A5090348913 @default.
- W2017339304 hasConcept C126322002 @default.
- W2017339304 hasConcept C134018914 @default.
- W2017339304 hasConcept C170493617 @default.
- W2017339304 hasConcept C185592680 @default.
- W2017339304 hasConcept C2776885963 @default.
- W2017339304 hasConcept C2778024521 @default.
- W2017339304 hasConcept C2778069365 @default.
- W2017339304 hasConcept C2778151854 @default.
- W2017339304 hasConcept C2779306644 @default.
- W2017339304 hasConcept C71924100 @default.
- W2017339304 hasConceptScore W2017339304C126322002 @default.
- W2017339304 hasConceptScore W2017339304C134018914 @default.
- W2017339304 hasConceptScore W2017339304C170493617 @default.
- W2017339304 hasConceptScore W2017339304C185592680 @default.
- W2017339304 hasConceptScore W2017339304C2776885963 @default.
- W2017339304 hasConceptScore W2017339304C2778024521 @default.
- W2017339304 hasConceptScore W2017339304C2778069365 @default.
- W2017339304 hasConceptScore W2017339304C2778151854 @default.
- W2017339304 hasConceptScore W2017339304C2779306644 @default.
- W2017339304 hasConceptScore W2017339304C71924100 @default.
- W2017339304 hasIssue "1" @default.
- W2017339304 hasLocation W20173393041 @default.
- W2017339304 hasLocation W20173393042 @default.
- W2017339304 hasOpenAccess W2017339304 @default.
- W2017339304 hasPrimaryLocation W20173393041 @default.
- W2017339304 hasRelatedWork W1971613811 @default.
- W2017339304 hasRelatedWork W1979676541 @default.
- W2017339304 hasRelatedWork W1997202516 @default.
- W2017339304 hasRelatedWork W2046811293 @default.
- W2017339304 hasRelatedWork W2050311658 @default.
- W2017339304 hasRelatedWork W2081556400 @default.
- W2017339304 hasRelatedWork W2089429297 @default.
- W2017339304 hasRelatedWork W2133240828 @default.
- W2017339304 hasRelatedWork W2468120394 @default.
- W2017339304 hasRelatedWork W2748952813 @default.
- W2017339304 hasVolume "351" @default.
- W2017339304 isParatext "false" @default.
- W2017339304 isRetracted "false" @default.