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- W2017339970 abstract "Conflict between mitogenic pressure, as is the case in tumour cells and an imposed inability to proceed through the cell cycle may result in cell death. In the present study we examined the effect of β galactoside binding protein (βGBP), a negative growth factor which controls cell cycle transition from S phase into G2, on three human mammary cell lines which differ for oncogenic potential, oestrogen receptor expression and expression of the EGF receptor family. We found that in all cases βGBP induced a cell cycle block prior to the cells’ entry into G2 and that this was followed by progressive apoptotic death. This evidence on epithelial cancer cells parallels previous data on tumour cells of mesenchymal origin and suggests that βGBP has potential therapeutic implications in the treatment of cancers." @default.
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- W2017339970 title "Cell cycle arrest and induction of apoptosis by β galactoside binding protein (βGBP) in human mammary cancer cells. A potential new approach to cancer control" @default.
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- W2017339970 doi "https://doi.org/10.1016/s0959-8049(99)00020-9" @default.
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