FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017341154> ?p ?o ?g. }

• W2017341154 endingPage "807" @default.
• W2017341154 startingPage "802" @default.
• W2017341154 abstract "BackgroundOutcomes of patients with lung adenocarcinomas can be predicted to some extent from the pathologic stage (p-stage). Although all attempts are made to fully remove cancer lesions, still a number of p-stage I patients without metastatic disease at the time of surgery develop recurrences and die of cancer. It is thus very important to identify p-stage I patients who are at risk of recurrence.MethodsPreviously, using microdissected samples, we identified metastasis-related genes. Using real-time reverse-transcriptase polymerase chain reaction analysis, we investigated the transcriptional levels of the top metastasis-related genes using 96 independent test lung adenocarcinoma samples and investigated their correlations with the prognosis.Results and ConclusionsWe document evidence that p-stage I patients with HOXB2 up-regulation have a worse prognosis than those with HOXB2 down-regulation (p = 0.0065), whereas the HOXB2 status has no prognostic significance for p-stage II–IV patients. Comparing tumors and corresponding normal lung tissue, we confirmed HOXB2 up-regulated lesions to have much higher HOXB2 expression than the corresponding normal tissue. Confirmation with a larger number of samples is needed, with further research to clarify the molecular functions of HOXB2. Outcomes of patients with lung adenocarcinomas can be predicted to some extent from the pathologic stage (p-stage). Although all attempts are made to fully remove cancer lesions, still a number of p-stage I patients without metastatic disease at the time of surgery develop recurrences and die of cancer. It is thus very important to identify p-stage I patients who are at risk of recurrence. Previously, using microdissected samples, we identified metastasis-related genes. Using real-time reverse-transcriptase polymerase chain reaction analysis, we investigated the transcriptional levels of the top metastasis-related genes using 96 independent test lung adenocarcinoma samples and investigated their correlations with the prognosis. We document evidence that p-stage I patients with HOXB2 up-regulation have a worse prognosis than those with HOXB2 down-regulation (p = 0.0065), whereas the HOXB2 status has no prognostic significance for p-stage II–IV patients. Comparing tumors and corresponding normal lung tissue, we confirmed HOXB2 up-regulated lesions to have much higher HOXB2 expression than the corresponding normal tissue. Confirmation with a larger number of samples is needed, with further research to clarify the molecular functions of HOXB2." @default.
• W2017341154 created "2016-06-24" @default.
• W2017341154 creator A5002072923 @default.
• W2017341154 creator A5004738203 @default.
• W2017341154 creator A5033251339 @default.
• W2017341154 creator A5033862426 @default.
• W2017341154 creator A5041853152 @default.
• W2017341154 creator A5046954073 @default.
• W2017341154 creator A5053961273 @default.
• W2017341154 creator A5069830757 @default.
• W2017341154 creator A5070262250 @default.
• W2017341154 creator A5088920500 @default.
• W2017341154 date "2007-09-01" @default.
• W2017341154 modified "2023-09-25" @default.
• W2017341154 title "HOXB2 as a Novel Prognostic Indicator for Stage I Lung Adenocarcinomas" @default.
• W2017341154 cites W135072275 @default.
• W2017341154 cites W1980115344 @default.
• W2017341154 cites W1991615434 @default.
• W2017341154 cites W1993312546 @default.
• W2017341154 cites W2005498969 @default.
• W2017341154 cites W2018665358 @default.
• W2017341154 cites W2021716162 @default.
• W2017341154 cites W2022027590 @default.
• W2017341154 cites W2030284436 @default.
• W2017341154 cites W2039442394 @default.
• W2017341154 cites W2046635710 @default.
• W2017341154 cites W2048249977 @default.
• W2017341154 cites W2075814987 @default.
• W2017341154 cites W2097934124 @default.
• W2017341154 cites W2099198356 @default.
• W2017341154 cites W2103274782 @default.
• W2017341154 cites W2105207670 @default.
• W2017341154 cites W2111507070 @default.
• W2017341154 cites W2121277505 @default.
• W2017341154 cites W2133040355 @default.
• W2017341154 cites W2133408651 @default.
• W2017341154 cites W2141891144 @default.
• W2017341154 cites W2161748901 @default.
• W2017341154 cites W2314681666 @default.
• W2017341154 doi "https://doi.org/10.1097/jto.0b013e3181461987" @default.
• W2017341154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17805056" @default.
• W2017341154 hasPublicationYear "2007" @default.
• W2017341154 type Work @default.
• W2017341154 sameAs 2017341154 @default.
• W2017341154 citedByCount "17" @default.
• W2017341154 countsByYear W20173411542013 @default.
• W2017341154 countsByYear W20173411542015 @default.
• W2017341154 countsByYear W20173411542017 @default.
• W2017341154 countsByYear W20173411542018 @default.
• W2017341154 countsByYear W20173411542021 @default.
• W2017341154 countsByYear W20173411542022 @default.
• W2017341154 crossrefType "journal-article" @default.
• W2017341154 hasAuthorship W2017341154A5002072923 @default.
• W2017341154 hasAuthorship W2017341154A5004738203 @default.
• W2017341154 hasAuthorship W2017341154A5033251339 @default.
• W2017341154 hasAuthorship W2017341154A5033862426 @default.
• W2017341154 hasAuthorship W2017341154A5041853152 @default.
• W2017341154 hasAuthorship W2017341154A5046954073 @default.
• W2017341154 hasAuthorship W2017341154A5053961273 @default.
• W2017341154 hasAuthorship W2017341154A5069830757 @default.
• W2017341154 hasAuthorship W2017341154A5070262250 @default.
• W2017341154 hasAuthorship W2017341154A5088920500 @default.
• W2017341154 hasBestOaLocation W20173411541 @default.
• W2017341154 hasConcept C121608353 @default.
• W2017341154 hasConcept C126322002 @default.
• W2017341154 hasConcept C142724271 @default.
• W2017341154 hasConcept C143998085 @default.
• W2017341154 hasConcept C146357865 @default.
• W2017341154 hasConcept C151730666 @default.
• W2017341154 hasConcept C2776178081 @default.
• W2017341154 hasConcept C2776256026 @default.
• W2017341154 hasConcept C2777714996 @default.
• W2017341154 hasConcept C2779013556 @default.
• W2017341154 hasConcept C2779134260 @default.
• W2017341154 hasConcept C2781182431 @default.
• W2017341154 hasConcept C71924100 @default.
• W2017341154 hasConcept C86803240 @default.
• W2017341154 hasConceptScore W2017341154C121608353 @default.
• W2017341154 hasConceptScore W2017341154C126322002 @default.
• W2017341154 hasConceptScore W2017341154C142724271 @default.
• W2017341154 hasConceptScore W2017341154C143998085 @default.
• W2017341154 hasConceptScore W2017341154C146357865 @default.
• W2017341154 hasConceptScore W2017341154C151730666 @default.
• W2017341154 hasConceptScore W2017341154C2776178081 @default.
• W2017341154 hasConceptScore W2017341154C2776256026 @default.
• W2017341154 hasConceptScore W2017341154C2777714996 @default.
• W2017341154 hasConceptScore W2017341154C2779013556 @default.
• W2017341154 hasConceptScore W2017341154C2779134260 @default.
• W2017341154 hasConceptScore W2017341154C2781182431 @default.
• W2017341154 hasConceptScore W2017341154C71924100 @default.
• W2017341154 hasConceptScore W2017341154C86803240 @default.
• W2017341154 hasIssue "9" @default.
• W2017341154 hasLocation W20173411541 @default.
• W2017341154 hasLocation W20173411542 @default.
• W2017341154 hasOpenAccess W2017341154 @default.
• W2017341154 hasPrimaryLocation W20173411541 @default.
• W2017341154 hasRelatedWork W1969927172 @default.
• W2017341154 hasRelatedWork W2364779800 @default.

• next