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• W2017341242 abstract "It has been suggested that drugs modulating the glutamate/N-methyl-d-aspartate (NMDA) receptor system may be useful in the treatment of alcohol dependence. The effect of neramexane, a low-to-moderate affinity uncompetitive NMDA receptor antagonist, was examined on the development and expression of ethanol dependence (withdrawal-associated audiogenic seizures) and ethanol-induced conditioned place preference. Neramexane hydrochloride (3.5 mg/kg and higher) inhibited both the development and expression of ethanol dependence. Neramexane hydrochloride also inhibited the acquisition (1.75 mg/kg and higher) and expression (3.5 mg/kg and higher) of ethanol-induced place preference. Our data support therapeutic potential of neramexane as a treatment for alcohol abuse." @default.
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• W2017341242 date "2004-10-01" @default.
• W2017341242 modified "2023-10-17" @default.
• W2017341242 title "Effect of neramexane on ethanol dependence and reinforcement" @default.
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• W2017341242 doi "https://doi.org/10.1016/j.ejphar.2004.09.036" @default.
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