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• W2017341312 abstract "Purpose.: Patients with dry eye syndrome, Stevens–Johnson syndrome, or recurrent transplant rejections are unsuitable to receive a keratoprosthesis. The present work aims at developing a highly biocompatible keratoprosthesis that could be successfully implanted in such patients. Methods.: Glass-reinforced hydroxyapatite (GRHA) was used to construct this new artificial cornea. To grant the device an adequate porosity, a porogen agent was added in the following percentages: 10, 30, and 50%. Samples were physicochemically analyzed in terms of density, porosity, roughness, degradation, and surface imaging. Biological relevance was assessed by cell culture, MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrasodium bromide) assays, and cell imaging. Results.: Samples B (30% porogen) and C (50% porogen) were found to be the most porous and also had the roughest topography. Degradation studies showed that under simulated physiologic conditions, no mass loss was found. Conversely, under acidic conditions, a significant mass loss was found. The biological performance of these samples was satisfactory when cultured with human fibroblasts. The MTT assay revealed that samples B and C had greater propensity to cell invasion and proliferation than that of the other tested materials. Cell imaging demonstrated that fibroblasts organized around the pore edges before colonizing it. Conclusions.: A material with physicochemical and biological characteristics close to an ideal artificial cornea has been fabricated. The GRHA cornea containing 30% porogen is the most promising substitute material due to the biological performance, adequate porosity, and low degradation propensity." @default.
• W2017341312 created "2016-06-24" @default.
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• W2017341312 date "2011-06-16" @default.
• W2017341312 modified "2023-09-29" @default.
• W2017341312 title "Degradation Studies and Biological Behavior on an Artificial Cornea Material" @default.
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• W2017341312 doi "https://doi.org/10.1167/iovs.10-6861" @default.
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