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- W2017343452 endingPage "340" @default.
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- W2017343452 abstract "The complement system is composed of soluble factors in plasma that enhance or “complement” immune‐mediated killing through innate and adaptive mechanisms. Activation of complement causes recruitment of immune cells; opsonization of coated cells; and direct killing of affected cells through a membrane attack complex (MAC). Tumor cells up‐regulate complement inhibitory factors – one of several strategies to evade the immune system. In many cases as the tumor progresses, dramatic increases in complement inhibitory factors are found on these cells. This review focuses on the classic complement pathway and the role of major complement inhibitory factors in cancer immune evasion as well as on how current protein engineering efforts are being employed to increase complement fixing or to reverse complement resistance leading to better therapeutic outcomes in oncology. Strategies discussed include engineering of antibodies to enhance complement fixation, antibodies that neutralize complement inhibitory proteins as well as engineered constructs that specifically target inhibition of the complement system." @default.
- W2017343452 created "2016-06-24" @default.
- W2017343452 creator A5029285661 @default.
- W2017343452 creator A5072667047 @default.
- W2017343452 date "2013-11-14" @default.
- W2017343452 modified "2023-09-29" @default.
- W2017343452 title "Protein engineering to target complement evasion in cancer" @default.
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- W2017343452 doi "https://doi.org/10.1016/j.febslet.2013.11.007" @default.
- W2017343452 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3894055" @default.
- W2017343452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24239543" @default.
- W2017343452 hasPublicationYear "2013" @default.
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