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• W2017345241 abstract "In order to study whether cytopathic HIV1 infection of haemopoietic progenitor cells is involved in the derangement of haemopoiesis in patients with HIV1 infection, we infected enriched progenitor cells with HIV1, by addition of viral inoculate supernatants from HIV1-infected peripheral blood mononuclear cells or by coculture with HIV1-infected monocytes/macrophages. Progenitor cells were seeded into colony assays and single colonies were chosen for HIV1 mRNA determination by in situ hybridization. Growth of progenitors was not affected by infection. However, up to 42% of colonies of pluripotent progenitor cells (colony-forming unit/granulocyte-erythrocyte-monocyte; CFU-GEM) and committed progenitor cells CFU/granulocyte-monocyte (CFM-GM) contained HIV1 mRNA-expressing cells. In addition, we studied HIV1 infection of progenitor cells from the bone marrow of 6 patients with AIDS or AIDS-related complex. Two patients were negative, two had a few colonies expressing HIV1 mRNA in a minority of cells, and in the remaining two, up to 11% of CFU-GM contained HIV1-expressing cells. Thus, infection of progenitor cells with HIV1 was achieved experimentally in vitro and occurs in vivo. However, growth of progenitors after in vitro infection continues and therefore HIV1 infection does not seem to contribute directly to the reduced incidence of haemopoietic progenitor cells in vivo. Afin d'analyser le dérèglement de l'hématopïèse chez les sujets infectés par le VIH, nous avons étudié l'infection virale des cellules souches (1) utilisées en prèsence de surnagealtde culles sanguines périphériques mononucléaires infectées par le VIH, ou (2) cocultivées avec des monocytes/macrophages infectés. Des colonies de cellules souches ont été isolées pour la détermination de l'ARNm viral par hybridization in situ. Le développement des cellules souches n'est pas affecté par l'infection. Cependant 42% des colonies de cellules souches pluripotentielles (unités formatrices de colonies/granulo-érythro-monocytaires, ou CFU-GEM) et de cellules souches ⪡engagées⪢ (granulo-monocytaires, ou CFU-GM) contenaient des cellules exprimant l'ARNm viral. De plus, nous avons étudié l'infection virale de cellules souches de la moelle de 6 malades souffrant de SIDA et d'ARC: 2 sujets étaient négatifs, 2 autres ont donné lieu à des colonies ARNm-VIH+ et pour les 2 derniers 11% des CFU-GM contenaient des cellules exprimant le virus. Ainsi, l'infection des cellules souches par le VIH1 a été obtenue expérimentalement in vitro et observée in vivo. Mais le développement des cellules souches aprés l'infection in vitro ne semble pas affecté; in vivo on ne devrait pas observer de relation directe." @default.
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• W2017345241 date "1991-01-01" @default.
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• W2017345241 title "Infection of granulocyte/monocyte progenitor cells with HIV1" @default.
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• W2017345241 doi "https://doi.org/10.1016/0923-2516(91)90052-5" @default.
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