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- W2017345783 abstract "Well-characterized antibodies against β-amyloid precursor protein (βAPP) and prion protein (PrP), and specific cRNA probes, were used to localize βAPP and PrP and their mRNAs in human muscle macrophages. Macrophages present in muscle biopsies of 51 patients with various neuromuscular disorders showed accumulation of βAPP and PrP, and strongly expressed βAPP and PrP mRNAs. These were present in all muscle macrophages unrelated to their localization within the muscle tissue or diagnosis. Our study provides the first demonstration that human muscle resident macrophages synthesize and accumulate βAPP and PrP. We suggest that those proteins play a role in biology of muscle macrophages, including their participation in inflammatory and immune responses." @default.
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- W2017345783 title "Human muscle macrophages express β-amyloid precursor and prion proteins and their mRNAs" @default.
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- W2017345783 doi "https://doi.org/10.1097/00001756-199505090-00024" @default.
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