FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017347042> ?p ?o ?g. }

• W2017347042 endingPage "2307" @default.
• W2017347042 startingPage "2299" @default.
• W2017347042 abstract "In this study, the bioactive effects of poly(ethylene glycol) (PEG) sebacic acid diacrylate (PEGSDA) hydrogels with or without RGD peptide modification on osteogenic differentiation and mineralization of marrow stromal cells (MSCs) were examined. In a separate experiment, the ability of PEGSDA hydrogel to serve as a delivery vehicle for bone morphogenetic protein 2 (BMP-2) was also investigated. As a scaffold, the attachment and proliferation of MSCs on PEGSDA hydrogel scaffolds with and without RGD peptide modification was similar to the control, tissue culture polystyrene. In contrast, cells were barely seen on unmodified PEG diacrylate (PEGDA) hydrogel throughout the culture period for up to 21 days. Osteogenic phenotypic expression such as alkaline phosphatase (ALP) of MSCs as well as mineralized calcium content were significantly higher on PEGSDA-based hydrogels than those on the control or PEGDA hydrogels. Potential use of PEGSDA scaffold as a delivery vehicle of osteogenic molecules such as BMP-2 was also evaluated. Initial burst release of BMP-2 from PEGSDA hydrogel scaffold (14.7%) was significantly reduced compared to PEGDA hydrogel scaffold (84.2%) during the first 3 days of a 21-day release period. ALP activity of an osteoblast was significantly higher in the presence of BMP-2 released from PEGSDA hydrogel scaffolds compared to that in the presence of BMP-2 released from PEGDA scaffolds, especially after 6 days of release. Overall, PEGSDA hydrogel scaffolds without further modification may be useful as orthopedic tissue engineering scaffolds as well as local drug carriers for prolonged sustained release of osteoinductive molecules." @default.
• W2017347042 created "2016-06-24" @default.
• W2017347042 creator A5014830665 @default.
• W2017347042 creator A5016934014 @default.
• W2017347042 creator A5036215756 @default.
• W2017347042 creator A5089189467 @default.
• W2017347042 date "2009-08-01" @default.
• W2017347042 modified "2023-09-25" @default.
• W2017347042 title "Potential of Hydrogels Based on Poly(Ethylene Glycol) and Sebacic Acid as Orthopedic Tissue Engineering Scaffolds" @default.
• W2017347042 cites W1551080197 @default.
• W2017347042 cites W1964514384 @default.
• W2017347042 cites W1970525947 @default.
• W2017347042 cites W1971254966 @default.
• W2017347042 cites W1974650456 @default.
• W2017347042 cites W1975836982 @default.
• W2017347042 cites W1978969388 @default.
• W2017347042 cites W1980223934 @default.
• W2017347042 cites W1980225254 @default.
• W2017347042 cites W1982691790 @default.
• W2017347042 cites W1986901350 @default.
• W2017347042 cites W2008850772 @default.
• W2017347042 cites W2013546498 @default.
• W2017347042 cites W2017502834 @default.
• W2017347042 cites W2018017628 @default.
• W2017347042 cites W2019672131 @default.
• W2017347042 cites W2023928940 @default.
• W2017347042 cites W2024621576 @default.
• W2017347042 cites W2037810763 @default.
• W2017347042 cites W2043669923 @default.
• W2017347042 cites W2044494246 @default.
• W2017347042 cites W2048888656 @default.
• W2017347042 cites W2059542554 @default.
• W2017347042 cites W2062224667 @default.
• W2017347042 cites W2073130464 @default.
• W2017347042 cites W2081789842 @default.
• W2017347042 cites W2094321766 @default.
• W2017347042 cites W2096943959 @default.
• W2017347042 cites W2102826200 @default.
• W2017347042 cites W2116319386 @default.
• W2017347042 cites W2122840995 @default.
• W2017347042 cites W2128118061 @default.
• W2017347042 cites W2131082021 @default.
• W2017347042 cites W2135354796 @default.
• W2017347042 cites W2154157809 @default.
• W2017347042 cites W2165694975 @default.
• W2017347042 cites W2333038355 @default.
• W2017347042 cites W2482531400 @default.
• W2017347042 cites W2506213463 @default.
• W2017347042 cites W4237331911 @default.
• W2017347042 cites W4248146720 @default.
• W2017347042 doi "https://doi.org/10.1089/ten.tea.2008.0326" @default.
• W2017347042 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2792107" @default.
• W2017347042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19292677" @default.
• W2017347042 hasPublicationYear "2009" @default.
• W2017347042 type Work @default.
• W2017347042 sameAs 2017347042 @default.
• W2017347042 citedByCount "36" @default.
• W2017347042 countsByYear W20173470422012 @default.
• W2017347042 countsByYear W20173470422013 @default.
• W2017347042 countsByYear W20173470422014 @default.
• W2017347042 countsByYear W20173470422015 @default.
• W2017347042 countsByYear W20173470422016 @default.
• W2017347042 countsByYear W20173470422017 @default.
• W2017347042 countsByYear W20173470422018 @default.
• W2017347042 countsByYear W20173470422019 @default.
• W2017347042 countsByYear W20173470422020 @default.
• W2017347042 countsByYear W20173470422021 @default.
• W2017347042 countsByYear W20173470422023 @default.
• W2017347042 crossrefType "journal-article" @default.
• W2017347042 hasAuthorship W2017347042A5014830665 @default.
• W2017347042 hasAuthorship W2017347042A5016934014 @default.
• W2017347042 hasAuthorship W2017347042A5036215756 @default.
• W2017347042 hasAuthorship W2017347042A5089189467 @default.
• W2017347042 hasBestOaLocation W20173470422 @default.
• W2017347042 hasConcept C108586683 @default.
• W2017347042 hasConcept C12554922 @default.
• W2017347042 hasConcept C136229726 @default.
• W2017347042 hasConcept C160160445 @default.
• W2017347042 hasConcept C178790620 @default.
• W2017347042 hasConcept C181199279 @default.
• W2017347042 hasConcept C185592680 @default.
• W2017347042 hasConcept C188027245 @default.
• W2017347042 hasConcept C198826908 @default.
• W2017347042 hasConcept C202751555 @default.
• W2017347042 hasConcept C2776407124 @default.
• W2017347042 hasConcept C2777516009 @default.
• W2017347042 hasConcept C30352789 @default.
• W2017347042 hasConcept C49892992 @default.
• W2017347042 hasConcept C55493867 @default.
• W2017347042 hasConcept C71924100 @default.
• W2017347042 hasConcept C86803240 @default.
• W2017347042 hasConcept C89429830 @default.
• W2017347042 hasConcept C95444343 @default.
• W2017347042 hasConceptScore W2017347042C108586683 @default.
• W2017347042 hasConceptScore W2017347042C12554922 @default.
• W2017347042 hasConceptScore W2017347042C136229726 @default.
• W2017347042 hasConceptScore W2017347042C160160445 @default.
• W2017347042 hasConceptScore W2017347042C178790620 @default.

• next